The Skin Irritation Of Ethylparaben And The Effect Of Spicy Food For It

Objective:Cosmetic dermatitis caused by undesirable for cosmetic skin reaction, Ensure that cosmetic products can be an effective non-degenerate long-term role of preservatives is one of the essential ingredients. Preservatives in cosmetics is an important place for cosmetic dermatitis causes, and whether, after eating spicy foods could enhance the body local reactions, The topics to be aimed at studying the spicy food of animal models continues to stimulate the state, one of the most'frequently used preservatives in cosmetics, Ethylparaben changes in skin irritation and thus the prevention and treatment of related diseases and provide experimental evidence.Methods:The 32 rabbits were randomly divided into four groups, control group, preservatives group, chili group, mixed group. The blank group and the preservative group was given normal saline 10ml/kg, saline 10ml/kg gavage, respectively; 10% Chilli Pepper group was given liquid 10ml/kg; mixed group was given 10% of the peppers and liquid 10ml/kg 50% alcohol 10ml/kg were fed daily a time,7d observed in rabbits after signs of the situation and score. The 8th day except the blank group were treated with preservatives smear the skin, as irritant, according to "Hygienic Standard for Cosmetics" skin irritation test methods and the steps and to determine rates, and separately in general and histopathological examination.Results:Compared with the control group, preservatives group appeared to stimulate the signs, pepper and mixed group of rabbits noticeable irritation signs, levels gradually increased, with statistical significance (P＜0.05). Ethylparaben experimental results show that a single skin irritation, mild spicy group of skin irritation skin reactions, compared with the preservatives group were statistically different (P＜0.05); repeated skin irritation experiments show that the skin had appeared spicy group mild and moderate skin irritation response, as compared with the preservatives group were statistically different (P＜0. 05)Conclusion:Ethylparaben with a mild skin irritation, according to the dose used in this experiment, spicy things can be induced in rabbits stimulated by signs spicy, this status can significantly enhance the Ethylparaben skin irritation. Diagnosis and treatment of related diseases in the daily should pay attention to the impact of eating spicy food.