Risk Factors Trasmission And Genotyping Research On Hepatitis C In Yanbian District

Research ObjectiveTo learn the risk factors and modes of transmission of HCV in Yanbian District, master the distribution of HCV viral genotypes, then explore the relationship between HCV genotypes and diseases development and treatment response. Provide measures which meet the actual demand for preventing disease happening and developing.Research MethodsAccording to 1:1 paired principle between case group and control group(the same sex, age extent not exceeding 5 years), used self-design questionnaires to investigate cases and controls, respectively 190 examples. And with fluorescent quantitation PCR detecting HCV genotypes distribution of 170 cases of HCV, measured biochemical indexes and HCV-RNA of these cases.Research Results(1) Simple factor analysis results showed that nation, habitation, clutrure level, family HCV, toothbrush in common, nail clippers in common, sharing a bath-towel, using condom, syringe in common, operation, blood transfusion or blood products, acupuncture, oral cavity diagnosis, endoscope, facies, tattooing, washing places and hair cutting or shaving, affcted HCV incidece rate(P<0.05). (2) Multiple factors Logistic Regression indicated that nation(OR=3.197), culture level(OR=2.156), family HCV(OR=0.249), toothbrush in common(OR=13.849), using condom(OR=0.282), blood transfusion or blood products(OR=0.190), acupuncture(OR=0.347), oral cavity diagnosis(OR=0.406), washing places(OR=2.204), hair cutting or shaving(OR=4.128), venereal disease(OR=1.573) and mother-infant transmission(OR=1.639), affected transmission of HCV. (3) The genotypes of HCV virus were 91 cases of 1b (56.2%),70 cases of 2a (43.2%), and 1case of ab (0.6%). (4) There were no differences between 1b and 2a genotypes on age, sex, nation, biochemical indexes excepting ALP(P>0.05). AST,ALT,ALP (2a gentype),GGT,TBIL,DBIL,PT,HCV-RNA in the case group were obviously higher than normal range values.Research Conclusion(1)Found out the main risk factors of HCV transmission in Yanbian District, such as blood transfusion history, operation history and other 10 indexes. There were statistical significance in use habit of condom, paid blood and education background between Han and Korea Peoples. (2) HCV viral genotypes in Yanbian District were maily as 1b and 2a types, but no difference in genetypes distribution between the two peoples. (3) Research results showed that genotypes was not related with route of infection. But virus content level in 1b type much higher than 2a type. (4) HCV genotypes was not correlated with malignant tumor of liver.