Age-related Macular Degeneration Syndromes And Its Key Pathogenesis Study

BackgroundAge-related macular degeneration (Age-related macular degeneration, ARMD), also known as age-related macular degeneration (senilemaeular degeneration, SMD, or aging macular degener-ation, AMD), is based on involving the retinal pigment epithelium (retinal pigment epithelium, RPE), photoreceptor cell layer and choroid-based multi-organization, a serious irreversible blinding eye disease. According to epidemiological findings, the disease has become the most important 65 years of age or older cause of blindness, age, the greater the higher the incidence of sex. In the UK, cataract, glaucoma, optic nerve atrophy and other disease rates are declining, while the AMD in the past four decades, an increase of 60%. In our country. With the modern society, material, spiritual progress, people's standard of living resulting improvement comes with the aging population growing, the incidence rates have increased year by year trend, but the disease is increasingly becoming the main One of the blinding eye disease, the disease is severe visual impairment in the elderly affecting the patient's symptoms, but also for patients and their families as well as I have brought a heavy financial burden, the above situation has attracted the close of ophthalmic Scholars Note that, and has had the disease as the eye focus of the study subject in the Prevention of Blindness.AMD pathogenesis remains unclear, in addition to increasing age, may also be environmental factors, biological factors, genetic mutations, chronic light damage, malnutrition, poisoning, autoimmune diseases, which may for a variety of factors, complex effects. AMD's syndrome differentiation in traditional Chinese medicine in the early Ming-Fang Wang believe that the disease usually caused by weak spleen and stomach, blood biochemistry lack source of qi and blood can not be on the commitments in the eyes, macular dystrophy, a long time then the spleen and stomach transportation of stolen Division, the body fluid metabolism disorders, wet muddy endogenous, the guilty head awakened, post-liver and kidney dystrophy, liver and kidney deficiency. Hence, under fundus findings will be summarized in this disease Spleen wet storm, phlegm and blood stasis and kidney deficiency three basic license types, Kwan-hwa, an important factor in the incidence of early spleen-deficiency. Grasp the syndrome is characterized by the cornerstone of clinical syndrome differentiation to find the etiology and pathogenesis, in particular, to master the main phases identified disease pathogenesis is the key to the treatment.PurposeThe project will use computer information science, epidemiology, statistics and so on, through the information retrieval, clinical research and other means for age-related macular degeneration and key characteristics of TCM syndromes of Disease study for further study and improve the age-related related macular degeneration in Chinese medicine syndrome differentiation and staging of disease differentiation treatment programs provide a scientific basis, so as to the clinical syndrome differentiation and treatment of age-related diseases provide an objective basis.Research MethodProspective randomized controlled clinical research methods, selection in January 2008-February 2009 during the Chinese medicine hospital of Guangdong Province, ophthalmic out-patient clinics and inpatient hospital visits in line with the inclusion criteria of a total of 40 cases of patients (63 eyes), by randomly divided into treatment group 20 cases and 20 cases of the control group, treatment group, male 9 patients (16 eyes),11 female pa-tients (17 eyes); Control group,9 male patients (14 eyes),11 female patients (16 eyes). Treatment group Shenling Baishu casual oral control group were given capsules of Vitamin E, Vitamin C tablets, Oral tablets inosine,8-week course of treatment, treatment of both pre-and post-treatment visual acuity, fundus examination, changes in Chinese medicine as well as the quality of life sy-mptoms areas such as observation, recording the course of treatment at any time of the evaluation target of Change, compared to the observations in order to systematic evaluation of Shenling Baishu San clinical potency for Trad-itional Chinese Medicine Treatment of sperm deficiency storm wet age-related macular degeneration provides objective basis for variability.The results1,6 times by cluster analysis, the age-related macular degeneration is closely related to clinical symptoms clustered together, drawn by TCM age-related macular degeneration syndromes and distribution. (1), liver-kidney:27 cases. (2) Spleen Weak:20 cases. (3) Yin Huo-wang-type:11 cases. (4), phlegm and blood stasis type:14 cases. (5) spleen wet storm type: eight cases. (6) qi stagnation:in 11 cases. (7) Blood deficiency:4 cases. 2, through the ages, occupations, bad habits and other factors analysis and the differences of different card types:1, increases with age, the age-related macular degeneration patients increased gradually, indicating age of onset of age-related macular degeneration risk one of the factors; 2,90 patients, staff engaged in other occupations in patients than in patients with more than survey the crowd engaged in staff, patients used the day as the eye longer than other professions long, and most of them need to use computers at work indicating burst Lu illumination time is age-related macular degeneration risk factor for disease; 3. smoking history:current smokers and former smokers, the risk of late AMD than non-smokers increased by 3.6-fold and 3.2-fold, indicating current smoking are risk factors, smoking is also a risk factor in the past.4. Environmental factors:studies have shown that the incidence of the disease in urban than rural.ConclusionAge-related macular degeneration standardization of TCM Syndrome research. By cluster analysis of age-related macular degeneration TCM type of liver and kidney, spleen weakness, Yin Huo-wang, phlegm and blood stasis, spleen wet storm, Qi stagnation blood stasis, qi and blood deficiency, including liver and kidney yin Deficiency most. With age-related macular degeneration TCM Syndrome Epidemic factors emerging from the study associated with age, occupation, bad habits, significant correlation.