The Effect Of Non-invasive Positive Pressure Ventilation On Serum NT-proBNP And IL-6 Concentration Of Acute Left Ventricular Failure Patients

Subjects:To observe the variation of the NT-proBNP and IL-6 level when the acute left ventricular failure patients are treated with non-invasive positive pressure ventilation (NIPPV).Methods:59 acute left ventricular failure patients were divided into NIPPV group and control group randomly. There were 30 patients and 29 patients for the 2 group respectively. All the patients were given oxygen, diuretic, vasodialator, inotropic, etc. Mechanical ventilation of non-invasive BiPAP mode was used in the NIPPV group combinationally. Serum NT-proBNP and IL-6 level, LVEF, CVP, PaO2, PaCO2, DO2, VO2 were assayed right before and 24 hours after treatment. The incident of intubation and motality between the two group were compared.Result:1. Serum NT-proBNP level, Serum IL-6 level, LVEF, CVP, PaO2, DO2, VO2 of NIPPV group improved significantly after treatment(P<0.05).2. In comparision with control group after treatment, Serum NT-proBNP level, Serum IL-6 level, PaO2, DO2, VO2 of NIPPV group were significantly higher. While CVP of NIPPV group was significantly higher and LVEF was higher(P>0.05).3. The intubation rate of NIPPV group was lower than control group(P<0.05). There are non-significant difference between the mortality of each group(P>0.05). Conclusion:Short term combinational NIPPV based on routine therapy on acute left ventricular failure patients significantly decrease serum NT-proBNP and IL-6 level, improve haemodynamic and oxygen dynamic, and depress intubation rate. However, it do not reduce the short-term mortality.