Efficacy Of Trimetazidine In The Treatment Of Ischemic Cardiomyopathy Heart Failure

ObjectiveToabserve the therapeutic effect of patient with ischem cardiomyopathy heart failure by trimetazidine treartment (2 months).MethodsAll patients were selected after application of digitalis preparations,angiotensin converting enzyme inhibitors,aldosterone antagonists, (3 blockers and diuretics and other conventional treatment. The treatment group adds in the conventional treatment foundation with trimetazidine 20mg 3/d. The medication observation period is 2 months。All patient 2 months later makes a follow-up visit 1 time, separately medication 1st day and the 2 month later measured that the blood pressure, the heart rate, and did electrocardiogram, the heart function evaluation, the heart color ultra inspection (measured left room diastole last stage inside diameter and left room shoot menstruation number) and the liver function, the kidney merit, the blood sugar, the blood fats, the blood, the routine urine test biochemistry inspection. The left room contraction function determination uses the American Phillips Corporation colored Doppler excess birth meter。Observation target:Around the treatment the blood pressure, the heart rate, the heart functional change, the electrocardiogram ST-T change and the left room diastole last stage inside diameter, the left room shoot, around the menstruation number the medication to inspect the liver function, the kidney merit, the blood sugar, the blood fats, the blood, the routine urine test change.Curative effect judgment:1. heart functional judgment standard:The treatment back of the body function improves above 2 levels is the appearance, improves 1 level is effectively, while the treatment back of the body function does not have the improvement or the aggravation is invalid; 2. electrocardiogram curative effect evaluation standard:Ceases activity the electrocardiogram anemic change to restore normal is the appearance, the ST section which electrocardiogram anemic drops rises again the inversion T wave shoal which above O.lmv either mainly leads unites to reach above 50% or the smooth T wave become the erectness the T wave to effectively, not be able to achieve the above standard invalid to。ResultsThe evident effective rate and the total clinical curative effective rate was,markedly exceeded in the treatment group control group (p<0.05).After the therapy,the LVEF were significantly increased both the control group and the treatment group (P<0.0001), the LVEDD were significantly decreased in the two groups (p<0.001),and the more evident effect in the trimetazidine group (p<0.05). ECG before and after treatment to compare the two groups was statistically significant (P<0.05), and on the liver and kidney function and hemodynamics had no effect.ConclusionCombined therapy of trimetazidine which does not affect the blood flow mechanics of the patients and conventional drugs improved the cardiac function in the patients with ischemic cardiomyopathy heart failure.