| ObjectiveTo evaluate the effectiveness of bone morphogenetic proteins-2/7(BMP-2/7) versus traditional standard treatment (include autograft, allograft and artificial material graft) in lumbar fusion.MethodsRandomized and quasi-randomized controlled trials were identified from Pubmed, EBSCO, Springer and CBM(Chinese Biological and Medical database).We handsearch the relative reference, Chinese and English orthopaedic journals. The data of the articles were evaluated by Jadad form. RevMan 5.0.18 were used to analysis the data.ResultsFourteen randomized or quasi-randomized controlled trials were included. The combined results showed that compare with the traditional standard treatment, using the BMP-2/7 in lumbar fusion proved:1. the higher fusion rate in the cases which used BMP-2 in anterior or posterior lumbar interbody fusion and posterolateral lumbar fusion, but using BMP-7 could not lead to higher fusion rate in posterolateral lumbar fusion,2. There is no better outcome when using BMP-2/7.ConclusionCompared with traditional standard treatment, the outcome of fusion with BMP-2/7 is similar but with higher fusion rate when using BMP-2 in lumbar fusion. |
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