| ObjectiveTo study the correlation between PTEN and p27 expression in gastric carcinoma and different grades intraepithelial neoplasia.MethodsImmunohistochemistry was applied to examine the expression of PTEN and p27 protein in 30 cases of normal gastric mucosa,30 cases of low grade intraepithelial neoplasia,30 cases of high grade intraepithelial neoplasia,30 cases of tumor-adjacent tissue and 30 cases of gastric carcinoma.ResultsIn normal gastric mucosa, low grade intraepithelial neoplasia, high grade intraepithelial neoplasia, tumor-adjacent tissue and gastric carcinoma, the positive rates of PTEN protein expression were respectively 100%,86.7%,83.3%,93.3%and 60.0%;the positive rates of p27 protein expression were respectively 100%,86.7%,83.3%,90.0%and 56.7%. The positive rates of PTEN and p27 expression in gastric carcinoma were lower than that in other tissues(P<0.05). The positive rates of PTEN and p27 expression in normal gastric mucosa was higher than that in low grade intraepithelial neoplasia and high grade intraepithelial neoplasia(P<0.05). The positive rates of PTEN and p27 expression in tumor-adjacent tissue had no difference with that in normal gastric mucosa(P>0.05). The positive rates of PTEN and p27 expression in low grade intraepithelial neoplasia had no difference with that in high grade intraepithelial neoplasia(P>0.05).The expression of PTEN and p27 in gastric carcinoma correlated with each other(r=0.384,P<0.05).ConclusionReduced expression of PTEN and p27 protein participates in the happen of low grade intraepithelial neoplasia,high grade intraepithelial neoplasia and gastric carcinoma.The expression levels of PTEN and p27 protein in gastric carcinoma and different grades intraepithelial neoplasia may be used to evaluate the development of gastric carcinoma. |
PDF Full Text Request