| Objective:To explore a way to early diagnosis and treatment for non-Hodgkin's lymphoma (NHL), and reveal the risk factors and prognosis-related factors.Methods:557 patients with NHL who were initially treated in the First Affiliated Hospital of Zhejiang University were enrolled. We retrospectively analyzed the distribution characteristics, pathological classification and clinical manifestations of these patients. Besides, follow-up study was preceded via phone to achieve data for survival status. Relationship between certain clinical indications and prognosis were evaluated.Results:Among the 557 cases studied, males were in the majority (male: female=1.9:1). The average age of patients was 51.5 years.305 cases(54.8%) were classified as extra-nodal NHL, and the most common extra-nodal sites were bone marrow (16.0%), gastrointestinal tract (14.6%) and followed by oral cavity (including gland, total 3.1%).425 cases(61.7%)were confirmed as B-NHL and 132 cases (37.1%) were confirmed as T-NHL. The common pathological subtypes were diffuse large B-cell lymphoma(50.2%), chronic lymphocytic leukemia/small lymphocytic lymphoma (7.6%), peripheral T-cell lymphoma, unspecified type (6.6%) and extra-nodal marginal zone B-cell lymphoma of MALT type(6.1%).124(22.2%) patients were in early stage at diagnosis while 433(77.8%) in advanced stage. Patients with T-NHL had a high rate of advanced stage(117,88.6%), B symptom (88,66.7%) and IPI score> 2 (83,62.9%) compared that of B-NHL,P<0.001,P<0.001,P=0.013 respectively. HBsAg positive was observed in 85(23.6%) patients with B-NHL and 9 (8.6%) in patients with T-NHL, P=0.001.38 (35.2%) patients with T-NHL experienced high level of triglyceride (TG) compared that of 98(26.5%) in B-NHL, P＜0.001. For patients with T-NHL, the median survival time for group of high level of TG was 6 months and 19.0 months for group of normal level of TG, P<0.0006.There were 65 (13.8%) patients with increased level of fast blood sugar,27.8%(120) patients with hypocalcaemia and 161(34.2%) patients with low level of high density lipoprotein-cholesterol (HDL-C) in NHL. The median survival time for group of hypocalcaemia was 10 months compared with 60 months in group of normal level of blood calcium, P＜0.0001. In B-NHL, the median survival time for group of low level of HDL-C was 49 months, while the group of normal level of HDL-C had not reached the median survival time P=0.012. The number was 15.0 months VS 42.0 months in T-NHL, P=0.001.Conclusion:This study shows that the incidence of NHL is higher in male than that in female. Extra-nodal NHL is more frequent than nodal NHL. The most common pathological subtype was diffuse large B-cell lymphoma. NHL is always diagnosed in advanced stage, especially in T-NHL. There is an increased HBV-infection rate in patients with B-NHL. And a high rate of TG abnormal is observed in T-NHL which predicts a bad prognosis. Patients with NHL are more likely to experience increased level of blood-fasting sugar and low level of HDL-C which may be the risk factors for developing NHL. HDL-C and blood calcium are also associated with overall survival. |
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