| Objective: To investigate the risk factors of DN via analyzing the concentration and relationship of paraoxonase-1(PON-1),SOD,MDA and insulin resistance in subjects with DN.Methods: 86 patients with T2DM were divided into two groups :48 patients without diabetic nephropathy and 38 patients with diabetic nephyropathy.Their serum PON-1,SOD,MDA and other indexes were measured,computed their HOMA-IR base on the clinical data.Clinical characteristics were compared in groups and analyzed the relationgship among them.The risk factors that may influence DN were performed by the logistic regressionmodel.Resuits: (1)The activities of serum PON-1 and SOD were significantly lower in patients with DN than those without DN(P<0.05); the levels of serum MDA were significantly higher in patients with DN than those without DN (P<0.05). (2)In the group with DN, the values of SBP,DBP,FINS and HOMA-IR were significantly higher than those in the group without DN(P<0.05). (3)The analysis of linear correlation showed PON-1 and SOD were negatively correlated with HOMA-IR. (4)Logistics regression analysis showed that serum MDA,SOD and SBP were associated with DN.Conclusion: (1)The activities of serum SOD were decreased while MDA were increased in the patients with DN, suggesting that there is oxidative stress. (2)PON-1 and SOD were correlated with insulin resistance. (3)The study showed that MDA,SOD and SBP were significantly risk factors for DN. |
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