The Analysis Of Risk Factors For Polypoid Lesions Of Gallbladder

Objectives The diagnosis of polypoid lesions of gallbladder (PLG) mainly rely on imaging and pathological examination. It is very difficult to differentiate benign and malignancy features in polypoid lesions of gallbladder. Therefore, learning from the experience of predecessors, The clinical manifestations, pathological and imaging features of the malignant and benign polypoid lesions were used to determine the risk factors of the malignant polypoid lesions.Materials and Methods The clinical data of 201 patients who were diagnosed as polypoid lesions of gallbladder and received cholecystectomy were reviewed and analyzed for age, sex, symptom, associated with gallstone, morphology of polypoid lesions of gallbladder, size of PLG, number of PLG, and preoperative tumor markers. SAS9.1.3 and Spss16.0 statistical software package were used, P< 0.05 is statistically significant.Results Benign PLG was found in 181 patients (90%), and malignant PLG was found in 20 patients(10%). Compared to benign group, the malignant group were older (61.6 vs 46.2,p< 0.0001). The morphology of malignant polypoid lesions were generally sessile (65.0% vs 11.05%, p<0.001). Malignant PLG tended to be larger (29.5mm vs 8.5mm,p<0.0001) and single lesion (80.0% vs 49.7%, p=0.01). Age over 60 years (P<0.001, odds ratio [OR],8.318), sessile morphology (P< 0.0001,odds ratio [OR],41.531), single lesion (p=0.0157,odds ratio [OR],1.296), and size over 10mm (P<0.001,odds ratio[OR],3.210) were identified as risk factors for malignant PLG.Conclusions Age over 60 years, sessile and single morphology of PLG, and the size of PLG over 10mm were the risk factors for polypoid lesions of gallbladder. Surgical intervention should be used for those with symptoms and with one or more risk factors. Those patients without risk factors should be followed-up.