The Effect Of Penehyclidine Hydrochloride On I-pH Of Patients In Nasal Endoscopic Surgery With Controlled Hypotension

Objective:The aim of our research was to evaluate the influence of penehyclidine hydrochloride on i-pH of patients in nasal endoscopic surgery with controlled hypotension and study the clinical significance.Methods:Thirty-six ASA class I or II patients scheduled for nasal endoscopic surgery were randomized into two groups including penehyclidine hydrochloride group (group P:penehyclidine hydrochloride was intravenous injected with 0. Olmg/kg 30 min before induction),and atropine group (group A:atropine was intramuscular injected at the same point with 0.5mg).The mean arterial blood pressure (MAP) was maintained 60-65% of initial parameters during controlled hypotension.After anesthesia induction, Tonocap was connected in both groups and continuously monitored the parameters, PgCO2 were recorded before the induction of controlled hypotension(TO), after the 0.5h (T1),1h(T2), and 0.5h (T3),1h (T4) after the termination of controlled hypotension.At the same time points,blood samples were taken in the tartal of foot for blood gas analysis. Intramucosal pH (i-PH) is got based on Henderson-Hasselbalch standard formula.Results:There was no obvious different in blood gas indexes among two groups. i-PH at T1, T2, T3 decreased obviously in both groups (P<0.05 orP<0.01) and the change in group A was more obvious (P<0.05 orP＜0.01). PgCO2 at T1, T2, T3and T4 increased obviously in both groups (P<0.05) and the change in group A was more obvious (P＜0.05 orP＜0.01)Conclusion:The effect of penehyclidine pydrochloride on gastrointestinal mucosal perfusion of patients in nasal endoscopic surgery with controlled hypotension was positive.