The Efficacy And Safety Of Postoperative Non-steroidal Antiinflammatory Drugs Therapy In Patients After Undergoing Total Hip Arthroplasty: Meta Analysis

AIM To determine the efficacy and safety of postoperative non-steroidal antiinflammatory drugs (NSAIDs) therapy in patients undergoing total hip arthroplasty using meta analysis.METHODS We searched PubMed, Embase, the Cochrane Library, Chinese biomedical literature database, CNKI,VIP and bibliographies of retrieved articles for randomized controlled trials comparing NSAID versus control after total hip arthroplasty (THA), we analyzed the data using Review Manager 5.0.RESULTS Thirteen randomized controlled trials totaling 4706 participants were included. The result of meta analysis showed that low dose aspirin did not significantly affect the incidence of heterotopic bone formation (HBF) [RR=0.99, 95%CI (0.87,1.14)] rather than medium to high dose NSAIDs [RR=0.44,95%CI (0.30,0.64)], there was no significant difference between two group in hip pain and physical function, incidence of HBF was 16.0% in NSAIDs-group and 11.1% in 7Gy group.CONCLUSION Apart from low dose aspirin, medium to high doses of postoperative NSAIDs produce a substantial reduction in the incidence of HBF at the cost of minor high gastrointestinal side effect. Limited evidence showed there were no significant differences between the groups for improvements in hip pain and physical function,7 Gy fraction is more effective than use of NSAIDs.