Study On PH/magnetic Double-sensitive Intelligent Hydrogel Drug Delivery System Loaded Albendazole

Objective Using chitosan(CS), Fe3O4 magnetite nanoparticles and sodium alginate(Alg) as main intelligent carriers, pH/magnetic double-sensitive intelligent hydrogel drug delivery system loaded albendazole(ABZ) was studied first time.Methods A novel pH sensitive magnetic Alg-CS hydrogel beads loaded ABZ were prepared by the ionic gelation method. Secondly, the physical and chemical characterization of the magnetic hydrogel were performed by SEM, FTIR and VSM respectively; The optimum preparation technique was investigated by single factor design and orthogonal test. Finally, encapsulation efficiency, loading efficiency, swelling behavior and cumulative release properties of ABZ from magnetic hydrogel beads at various pH were investigated.Results The results showed that the surface morphology of the magnetic Alg-CS hydrogel beads using the optimum preparation technique by orthogonal test was spherical, regular and dark brown before dried. The saturation magnetization (σs) of the magnetic hydrogel Alg-CS beads was about 15.13 emu/g showed that the magnetic Alg-CS hydrogel beads had superparamagnetic property as well as fast magnetic response. The beads had showed unique pH-dependent swelling behaviors. In vitro release behavior of the magnetic Alg-CS hydrogel beads presented pH sensitivity. Within 2 h, the amount of ABZ released from the magnetic hydrogel beads was relatively low (36.36%) at pH 1.5, while that released at pH 6.8 increased significantly (60.61%). Within 16 h, ABZ released from the magnetic beads was 88.95%at pH 1.5,93.93% at pH 6.8, while that released was the lowest (10.47%) at pH 2.5. The sequential release results showed that the percent of ABZ released from magnetic Alg-CS hydrogel beads was 44.15%within 3 h in SGF (pH1.5), however, the amount of ABZ released increased significantly at pH6.8 (approximately 98.92%) after 19 hour. The release of ABZ from the magnetic beads at various pH values was analyzed by a semi-empirical equation and it was found that ABZ release from magnetic Alg-CS beads was controlled both by diffusion and disintegration of the magnetic Alg-CS gel matrix. Conclusion Magnetic Alg-CS hydrogel beads loaded ABZ could be further developed for a pH/magnetic double-sensitive intelligent drug delivery system suitable for intestine administration. The magnetic hydrogel beads could be located by a powerful magnetic field (MF) in the target site where the parasites lived and ABZ could be released continuously. ABZ released from magnetic hydrogel beads in situ, timing and quantitatively in intestinal tract. Therefore, this intelligent drug delivery system could against parasite in intestinal tract, decrease administration times, minimize the side effects of ABZ.