The Clinical And Empirimental Study Of Tongfengfang Decoction In The Treatment Of Gout

ObjectiveThrough collecting, arraging, inducing, and analyzing outpatient case, we discuss the effect of Tongfengfang decoction in the treatment of gout, as the same time, we carry the experiment which uses hypoxanthine and potassium oxonate to create a model of hyperuricemia in rats, to further clarify the effect of Tongfengfang in the treatment of gout, and provide the experimental evidence for therapeutic efficacy of clinic.MethodsThrough retrospective study,we collected,classified, induced the basic information, symptoms of the 30 patients who were from the Guangdong Provincial Hospital rheumatology clinic from May 2008 to March 2010, who met the inclusion criteria of the collection;Simutaneously,we analyzed the category of gout and the changes after treatment. so we can make an objective evaluation about clinical efficacy of Tongfengfang decoction. Using hypoxanthine and potassium oxonate to create a model of hyperuricemia in rats, and by testing serum uric acid, XOD, observing the number of animals writhing, we can observe the effect of Tongfengfang Decoction 1,2,3 in reducing uric acid and XOD and the pain relief.Results1.The whole distribution of symptoms of TCM:30 patients were included in the study, the patients of wind-cold-damp sybdrome accounted for 3.3%; The patients of wind-heat-damp sybdrome accounted for 66.7%;The patients of damp-phlegm-stagnant-blood sybdrome accounted for 26.7%; liver-kindey deficiency sybdrome accounted for 3.3%;2.The assessment of therapeutic effect:30 cases included in this study in patients with gout were administrated by Tongfengfang decoction. After 1 week, among the 30 patients,1 patient was clinical control;14 patients were obvious effective;13 patients were effective; the total effective was 93.3%;After 1 week, among the 30 patients,5 patient were clinical control;13 patients were obvious effective; 11 patients were effective; the total effective was 96.7%;3. Comparison of clinical symptoms:After 1 week,2 weeks, the joint pain index, the joint swelling index, which compared with the symptoms before two weeks, were significant differences (P<0.05).4. The experiment results:each dose group of TFF1, the high dose group of TFF2, the high and model dose group of TFF3, comparede with control group, uric acid were decreased. TFF1 middle and high dose group, TFF3 high dose group compared with the positive control group was statistically significant. TFF1 (middle and high dose group)decrease the concentration of xanthine oxidase (P<0.01) compared with the positive control group. TFF3 (high dose group) comparing with the postive control group, the concentration of xanthine oxidase decreased(P<0.05), Easing pain experiment:Comparing with the positive group, the middle and high dose group of TFF1 and the high dose group of TFF3 were significant differences. Gouty arthritis model experiments:TFF1 (low, medium and high dose group)compared with the the model group:the swelling decrease followed by a low dose to high dose increased; TFF3 (medium and high dose group)compared with the the model group:the joint swelling gradually decreased.ConclusionThere were significant improvement in the aspect of clinical symptome when patients were administrated by Tongfengfang decoction. The model of hyperuricemia showed:Tongfengfang decoction could decrease uric acid and xanthine oxidase level significantly.Simutaneously, the decoction also had significant analgesic, anti-inflammatory effects, and provided a strong experimental evidence for the good clinical effect.