Expression Of HMGA1 In The Patients With Lung Squamous Cancer And Its Clinical Prognostic Significance

ObjectivesTo investigate the expression of HMGA1 in the patients with lung squamous cancer and its clinical prognostic significanceMethodsThe expression level of HMGA1 in 47 patients with lung squamous cancer and 8 cases of control lung tissue was detected by immunohistochemistry and its corelation to clinic pathological paramter was analyzed statistically。ResultPositive rates of HMGA1 protein was 68.1%(32/47)and 12.5%(1/8)in lung cancer and in lung tissue of control group, respectively, and the difference was significant(P<0.05); No significant relationship was found between HMGA1 and patients sex or age (P>0.05).ConclusionsThe progression of the lung cancer may relate with the increase of HMGA1 expression. It's promising for HMGA1 to become a new marker for diagnosis of lung squamous carcinoma. Clinical detecting of HMGA1 could help with prognosis and treatment-guiding of lung squamous cancer.