| Backgrounds and objections:CHD refers to coronary atherosclerosis stenosis or obstruction, leading to myocardial ischemia, hypoxia caused by heart disease. AS is one of the major cause of death in Western countries. As the improved living standards of our people and eating habits change, this disease has also become the main cause of death in China. From the view of the pathogenesis of CHD, AS, whose formation process is a complex process is pathological basis. Dyslipidemia especially the elevated LDL and OX-LDL has a controlling influence over the process of AS occurrence and development. LDL which deposites in the arterial wall induces chemotaxis of chemoattractant to vascular endothelium, and then monocytes transform into macrophages under endangium. The latter can generate free radical to make LDL oxidizing to OX-LDL. OX-LDL can be unlimited taken into macrophages by phagocytosis to form foam cells which are the basis for the formation of AS. Some studies at home and abroad have shown that AS is a kind of disease which involves inflammation and immune systems. Immunogenic OX-LDL induces the body to produce specific antibodies which can form immune complexes with OX-LDL. This kind of immune complexes lead more OX-LDL being taken by macrophages and form more foam cells. All these show the importance of LDL and OX-LDL in AS. According to the clinical manifestations CHD are divided into SAP, UAP, and AMI. In this study, control group are people with normal coronary arteries. This study is to discuss the relationship between LDL, OX-LDL and SAP group, UAP group, AMI guoup and contaction of LDL and OX-LDL. The purpose is to provide a scientific basis for CHD diagnosis, treatment and prevention.Research Methods:Experimental group are 300 CHD patients without taking lipid-lowering drugs more than a month who admittde in the depatrment of cardiolysis from August 2008 to August 2009. They are divided into SAP group(100 cases),UAP group(100 cases),AMI(100 cases). The control group are 100 cases of patients who are randomly selected and confirmed without AS by coronary angiography in the same period in our department. Those cases has complete medical history, basic information and various laboratory test results. Basic information includs gender, age, smoking, drinking, hypertension, diabetes. Laboratory tests include levels of LDL (measured by enzyme colorimetric method) and OX-LDL (measured by ELISA method). By retrospective case analysis we study patients'basic information, the level and correlation of LDL and OX-LDL in control group, SAP group, UAP group, AMI group.Results:1 there are no significant differents between AMI group, UAP group, SAP group and control group in clinical background, such as, age, sex, smoking, alcohol consumption, hypertension, diabetes(P>0.05).2 Concentration of OX-LDL in AMI group is significant difference compared with USP group(P<0.01). Concentration of LDL in AMI group is not significant difference compared with UAP group (P>0.05). Concentration of OX-LDL and LDL in AMI group is significant difference compared with SAP group and control group(P<0.01). Concentration of OX-LDL in UAP group is significant difference compared with SAP group(P<0.05). Concentration of LDL in UAP group is not significant difference compared with SAP group(P>0.05). Concentration of OX-LDL and LDL in UAP group is significant difference compared with control group(P<0.01). Concentration of OX-LDL and LDL in SAP group is significant difference compared with control group (P<0.01).3 There is correlation between concentration of LDL and OX-LDL in CHD group (r=0.2143, P>0.05).Conclusions:1 We confirm that LDL and OX-LDL are risk factors for CHD. They associate with the severity of CHD.2 There is correlation between concentration of LDL and OX-LDL in CHD group(r=0.2143, P>0.05).3 Although OX-LDL was correlated with LDL, OX-LDL play a more important role in the process of AS. Compared with LDL, OX-LDL which is determined by using ELISA is more meaningful in the treatment and prevention of CHD.
|
PDF Full Text Request