The Relationship Between Regulated On Activation In Normal T Cell Expressed And Secreted And Type 2 Diabetic Kidney Disease

Objective To investigate the relationship between regulated on activation in normal T cell expressed and secreted(RANTES) and type 2 diabetic kidney disease.Methods Diabetic kidney disease was classified into the following 3 stages according to urinary albumin-to-creatinine ratio (ACR):non-diabetic kidney disease,incipient diabetic kidney disease,and clinical diabetic kidney disease.The levels of serum RANTES and other clinical datas were measured in 60 patients with type 2 diabetic kidney disease and 20 healthy adults as control.Results The levels of serum RANTES of group DM was(489.15±32.03)ng/ ml,compaired with group DKD1 (600.22±36.84)ng/mL,and group DKD2 (725.65±53.95)ng/mL.The levels of serum RANTES in all the patients with diabetic kidney disease were significantly higher than those of healthy adults. RANTES in the patients with diabetic kidney disease increased gradually according to the clinical stage of this disease.There was a positive correlation between the levels of serum RANTES and disease course, systolic pressure, diastolic pressure, fasting blood glucose,glycosylated hemoglobin, serum creatinine and hs-CRP.Conclusion The level of serum RANTES was closely related to the occurrence and development of type 2 diabetic kidney disease,it indicated that RANTES was involved in DKD. RANTES may be an important inflammation index in DKD.