The Abnormal Presentation And Significance Of T-cadherin Molecules In Breast Cancer

Objective:By detecting breast cancer,adjacent normal tissues,breast fibroadenoma and normal breast tissue in T-cadherin expression,analysis of different breast tissues between T-cadherin expression;of T-cadherin Expression in Breast factors.Methods:Immunohistochemical SP method were detected in 50 cases of breast cancer,20 cases of adjacent normal tissues,20 cases of breast fibroadenoma,10 cases of normal breast tissue T-cadherin expression,analysis of breast tissue in each group T-cadherin Differential expression;of T-cadherin expression and clinical pathological factors in breast cancer.Results:1,T-cadherin staining was mainly located in the basal membrane and basal cells, especially cells-cells displayed the most obvious,is light yellow to brown granules. The group of normal breast tissue,fibroadenoma breast tissue,breast tissue most adjacent ductal epithelial cells were strongly positive or positive staining, non-staining cytoplasm;in some tumor cells in breast cancer yellow to brown The number of yellow stained particles significantly reduced or non-staining,and the cytoplasm of tumor cells were found to varying degrees,abnormal expression of T-cadherin distribution(37 cases:31 cases of invasive ductal carcinoma,ductal carcinoma in 3 patients,2 cases of mucinous adenocarcinoma,Medullary carcinoma 1 case),T-cadherin in normal breast,fibroadenoma of breast tissue,adjacent normal tissues,the positive expression rate was 100%(10/10),95.0%(19/20),95.0%(19/20); T- cadherin in breast cancer,the positive expression rate was 40%(20/50);by the test χ~2,T-cadherin in breast cancer,adjacent normal tissues,tumor tissues and normal breast tissue expression of positive difference statistically significant(P＜0.001),and further to do 22 more(adjusted test leveα'=0.0083),respectively,than breast cancer group and in adjacent normal tissues,tumor tissues,normal breast tissue were significantly different between the three groups of foreign The other three groups were doing 22 There were no significant differences.That T-cadherin in breast cancer positive expression rate(40.0%) was significantly lower than in adjacent normal tissues of 95.0%(χ~2=8.333,P=0.004),lower than the tumor tissues of 95.0%(χ~2= 8.333,P=0.004),lower than normal breast tissue of 100.0%(χ~2=11.20,P=0.001); and in adjacent normal tissues,tumor tissues and normal breast tissue and comparisons between T-cadherin expression was not significant(P＞0.0083). 2,T-cadherin expression in breast cancer rates with TNM stage and lymph node metastasis associated with two factors,including:TNM stages between the three groups T-cadherin expression in the same failure rate,Ⅲ,Ⅳstage breast cancer T-cadherin positive expression rate was 12.5%,significantly lower than in stageⅠ(60.0%) andⅡ(47.4%) groups,the differences between the three groups was statistically significant(χ~2=7.971,P=0.019),further 22 more(adjusted test leveα'= 0.017),TNM stage and TNM stageⅠ,Ⅲ,Ⅳperiod between the T-cadherin expression and there was significant statistical difference(calculated exact test P= 0.009),TNM stageⅢ,Ⅳstage of T-cadherin expression was significantly lower than the TNM stageⅠ,the positive rate;and TNM staging TNM stageⅠandⅡstage, TNM stage and TNM stageⅡ,Ⅲ,Ⅳof expression between T-cadherin was no significant difference(exact probability method was,respectively P=0.51;P=0.035). Patients with axillary lymph node T-cadherin expression was lower than in patients without axillary lymph node positive rate(χ~2=5.556,P=0.018).T-cadherin expression in breast cancer rates with age,tumor diameter,tumor size,histological grade,ER,PR,Cer-bB-2 and other factors not significant,the difference was not statistically significant. Conclusions.1,Breast Cancer T-cadherin molecule expression rate than in noncancerous breast tissue,breast tumor tissues and normal breast tissue was significantly reduced (decrease or absence),in cancer development and the process may play a tumor suppressor gene role.2,Breast Cancer T-cadherin molecules down with tumor TNM stage and lymph node metastasis is closely related,suggesting that tumors with malignant progression, T-cadherin molecules were decreased.