Clinical Research Of Influenza A H1N1 Influenza Patients

Aim:This study aimed to investigate the neutrophils, lymphocytes, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) in influenza A/H1N1 influenza critically ill patients in changes and evaluation of thalidomide in patients with influenza A/H1N1 influenza T-cell subsets.Method:During November 2009 and January 2010, we observed 30 persons infected influenza A (H1N1) virus who were quarantined in The First Affiliated Hospital of Kunming Medical College in ICU. Oxygenation index of 200 as the boundary grouping, divided into the oxygenation index>200 group and oxygenation index<200 group. Monitor blood count, erythrocyte sedimentation rate (ESR), C reactive protein (CRP). According to oral thalidomide, it is divided into thalidomide group and control group, monitoring peripheral blood T lymphocyte subsets.Result:1. Erythrocyte Sedimentation Rate (ESR):Compared with oxygenation index>200 group (29.36±22.24 mm/h), the first day of admission oxygenation index<200 group's ESR (27.33±19.31 mm/h) was decreased, P=0.012, P<0.05.2. C-reactive protein (CRP):Influenza A/H1N1 influenza patients's CRP general mean was decreased, from the first day of hospitalization (72.96±70.96 mg/1) decreased from the fourth day (39.35±38.04 mg/1). The first day of admission, compared with oxygenation index>200 group (59.37±50.90mg/l), oxygenation index<200 group's CRP (82.55±81.34mg/l) was significantly higher, P=0.023,P<0.05.3. Compared with admission, the fifth day of treatment, the total T lymphocytes, T helper cells, T cell suppression and Th/Ts ratios were higher, P<0.05, differences were statistically significant; Compared with before treatment, after oral administration of thalidomide in patients with Th/Ts ratio increased, P=0.047, P<0.05.Conclusions:1. Influenza A/H1N1 influenza in patients's ESR on admission at 28 mm/h-48mm/h, influenza A/H1N1 influenza critically ill patients's ESR was significantly decreased.2. Influenza A/H1N1 influenza in patients's CRP on admission< 77 mg/1, Influenza A/H1N1 influenza critically ill patients's CRP was significantly higher.3. The cellular immune function decreased in Influenza A/H1N1 influenza patients. Thalidomide can be adjustable Influenza A/H1N1 influenza in patients with cellular immune function, so that Th/Ts ratio increased.