The Clinical Analysis Between Myocardial Enzyme Changes And Hyperglycemic Hyperosmolar Status

Objective: To explore the causes and related factors of hyperglycemic hyperosmolar status patients with myocardial enzyme changes. Methods: 46 cases of diabetes mellitus (DM) were divided into two groups: Group A includes 24 cases with hyperglycemic hyperosmolar status (HHS), plasma osmotic pressure is higher than 320mmol/L. Group B includes 22 cases diabetes without acute complications, plasma osmotic pressure is lower than 310mmol/L. Myocardial enzyme were detected in all cases and compared. The biochemical features of the patients include glucose, Na~+, uric acid in serum, plasma osmotic pressure were conducted a correlation analysis with myocardial enzyme. The clinical data were analyzed with SPSS13.0. Results: 1. The activities of Aspartate aminotransferase (AST), creatine kinase isoenzyme(CK), creatine kinase isoenzymeMB (CK-MB), lactate dehydrogenase (LDH) and a-hydroxybutytate (HBDH) in the group A were significantly higher than that in group B (P < 0.05). 2. AST, CK, CK-MB, LDH, HBDH were significantly positively correlated with plasma osmotic pressure, CK were positively correlated with serum uric acid too. Conclusions: 1. Noninjuria rhabdomyolysis is easily induced by HHS, myocardial enzyme, especially CK shoude be monitored routinely at the first a few days after admission. 2. The mainly related factor of myocardial enzyme changes in HHS is plasma osmotic pressure.