The Research Of The Pathological Nature And Syndrome Characteristics And The Main Treatment Of The Syndrome Of The Elderly Asthenia Of Kidney And The Sensory Orifices Obstruction Of Phlegm-stasis

The research is under the guidance of Chinese traditional medicine, Combined with modern medical knowledge, through theoretical analysis and animal experiments, going deep into study on the Pathological nature and Syndrome characteristics and the main treatment of the Syndrome of the elderly asthenia of kidney and phlegm-stasis obstructs the sensory orifices. coming to the conclusion that the fundamental pathological factors of the syndrome is asthenia of kidney, phlegm-stasis, obstructing the sensory orifices. the performance of disease is general body dysfunction, vascular obstruction, dull-witted. in connection with the pathogenesis, the fundamental treatment is nourishing the kidney and resolving phlegm-stasis for resuscitation, based on the san jia san created by WU YOUKE, take the improved san jia san to nourish Yin and descend Yang, nourish the essence and The Sea of marrow, make the colleteral fluent and recover the resuscitation. If there is the characterized performance of the syndrome, such as Memory decline,Unresponsive,Looked sluggish,Mental disorder,Sensory disturbance,Dysfunction of body and Organs and so on, we can use the treatment of nourishing the kidney and resolving phlegm-stasis for resuscitation flexibly. Making use of the improved san jia san can receive a good therapeutic effect in the common clinical encephalopathy of the elderly listed.In order to explore the mechanism of the treatment of nourishing the kidney and resolving phlegm-stasis for resuscitation and the effect of the improved san jia san, we have successfully developed the rat model of Alzheimer's, by means of injecting D-Gal into rat peritoneal, to realize acute aging, then by way of slow injecting Aβ1-42 and Ibo into hippocampus, Successful establishment of AD animal model is realized, taking use of drug therapy of san jia san, Western medicine and rehabilitation of brain to compare the efficacy, and then, experimental study on it, including behavior Study and pathology. results show that the prescription has a good effect on improving memory, the mechanism may be by means of enhancing the activity of Monoamine oxidase,restraining Amyloid precursor protein gene,promoting nerve growth factor to grow, Thus anti-aging,Rat reducing brain Amyloid deposition, saving AD degeneration of neurons are accomplished. thus they are further evidence of the Mechanism and effect of our treatment and Prescription.