Experimental Study On Effect Of PDGF And IGF-1 Expression On ERM Of Huo Xue Li Shui Method On Traumatic Proliferative Vitreoretinopathy In Rabbits

Objective: To study the curative and preventive effects and mechanism of HuoXueLiSui Method (HXLSM) on traumatic proliferative vitreoretinopathy.Methods: 32 rabbits were selected randomly from 40 rabbits and induced to traumatic proliferative vitreoretinopathy models, then divided into four groups: the first group was treated with San Xue Ming Mu Tablet - Huo Xue Li Shui (HXLS) group, the second treated with Zhi Xue Qu Yu Tablet -Huo Xue Hua Yu(HXHY) group, the third treated with Zhu Ling San - Li Shui Ming Mu(LSMM) group and the model group . The rest 8 formed the blank control group. After the rabbits had been fed and administrated for 28 days, we observed the visibility of fundus, the degree of PVR and pathologic changes, measured the positive levels of platelet-derived growth factor(PDGF) and insulin-like growth factor 1 (IGF-1) in epiretinal membrane(ERM).Results: Compared with model group ,the positive level of PDGF and IGF-1 was decreased significantly in HXLS group (p<0.01). Compared with model group, the positive level of PDGF and IGF-1 decreased much in HXHY and LSMM group(p<0.05).And the level of PDGF and IGF-1 in HXLS group were lower than those in HXHY and LSMM group. The positive level of PDGF and IGF-1 group was a little higher than those in blank group (p<0.05). The PVR in HXLS group was lighter than that in model group,HXHY and LSMM group.Conclusions: HXLS method is the coordination of HXHY method and LSMM method. It could inhibit and cure the formation and development of traumatic PVR by counteracting the expression of PDGF and IGF-1 on ERM as to inhibiting proliferrative cell's hyperplasy.