Epidemiologic Investigation Of Preterm Infants Hospitalized In The City Of Changsha

ObjectIn order to establish a foundation for further epidemiological survey of preterm infants throughout the city of Changsha,this paper collected and analyzed medical documents of preterm infants hospitalized in the city of Changsha.Methods1.All preterm infants hospitalized in the Second Xiang Ya Hospital Of Central-South University,the Maternal and Child Heath Hospital of Hunan Province and the Maternal and Child Health Hospital of Liuyang between January 2008 and December 2008 were enrolled in this study. Major causes and neonatal diseases associated premature birth and incidence of preterm infants were investigated retrospectively.2.Statistical analysis:Apply of the Statistical Package for SPSS16.0, The enumeration data was analyzed statistically by chi-square test(hours use of sample size Fisher's Exact Test),correlation analysis was processed among the neonatal diseases,gestational age or birth weight. Logistic regression analysis was used to the outcome of the risk factors.Results1.This paper collected with a gender constituent ration of 1.26:1 (boy:girl).Gestational age according to different sub-groups:gestational age≦28 weeks 1.1%,28～32 weeks accounted for 15.8%,＞32weeks accounted for 83.1%.Birth weight according to different sub-groups: birth weight＜1000g accounted for 0.7%,～1500g accounted for 11.1%, 2500g accounted for 61.3%,≥2500g accounted for 26.9%.2.The most common precipitating factor of preterm birth was the premature rupture of membranes(41.6%),followed by multiple pregnancy(28.9%),pregnancy-induced hypertension syndrome(16.6%), infected mother during pregnancy(13.1%) and placenta previa(6.8%) and so on.3.The most common neonatal disease was respiratory system diseases(73.8%),followed by Infectious diseases(39.4%),nervous system diseases(38.3%),metabolic acidosis(28.9%),hyperbilirubinemia (22.9%),etc.4.The incident of neonatal diseases decreased with the increase of gestational age or birth weight.With the increase of gestational age or birth weight,a significant decrease in the incidence of neonatal diseases except circulatory system diseases was also observed(P＜0.05).The desirable outcome of the premature infant rose with the increase of gestational age or birth weight(P＜0.05).5.In addition to congenital heart disease with gestational age was no significant correlation(P＞0.05),the neonatal pneumonia,neonatal respiratory distress syndrome,apnea,pulmonary hemorrhage,neonatal infections(sepsis),intracranial hemorrhage,brain injury in preterm infants,feeding intolerance,hyperbilirubinemia,neonatal asphyxia, metabolic acidosis,glucose metabolism disorders and newborn scleredema were negatively correlated with gestational age(P＜0.05 );in addition to congenital heart disease,hyperbilirubinemia with birth weight was no significant correlation(P＞0.05),the neonatal pneumonia,neonatal respiratory distress syndrome,apnea,pulmonary hemorrhage,neonatal infections(sepsis),intracranial hemorrhage,brain injury in preterm infants,feeding intolerance,neonatal asphyxia,metabolic acidosis, glucose metabolism disorders and newborn scleredema were negatively correlated with birth weight,gestational age(P＜0.05);the desirable outcome of the premature infant and gestational age,birth weight was positively correlated(P＜0.05).6.Increase in birth weight or gestational age was the outcome of a protective factor;neonatal asphyxia,hyperbilirubinemia,neonatal scleredema,glucose metabolism disorders,neonatal infections(sepsis), intracranial hemorrhage were the impact of premature infants within 28 days after birth outcome risk factors.Conclusions1.The major causes of premature were premature rupture of membranes,multiple pregnancy and pregnancy-induced hypertension syndrome,et al.2.The most common neonatal disease was respiratory system diseases,newborn infection(septicemia),nervous system diseases,etc; the incident of neonatal diseases decreased with the increase of gestational age or birth weight.As the gestational age,birth weight improved,cure rates rise.3.Birth weight and gestational age were the outcome of protective factors;neonatal asphyxia,hyperbilirubinemia,neonatal scteredema, neonatal infections(sepsis),intracranial hemorrhage were the impact of premature infants within 28 days after birth outcome risk factors.