| The aim of this research subject was to develop experimental prototype of alternating magnetic field generator for hyperthermia treatment of tumors with magnetic nanoparticles, and researched magnetocaloric effect of Fe3O4 nano-magnetic liquid.Hyperthermia treatment of tumors with magnetic nanoparticles was that injected magnetic nanoparticles into tumors, then magnetic nanoparticles targeted tumor focal lesions. Magnetic nanoparticles released energy under alternating magnetic field, the temperature of tumor focal lesions would rise, and normal tissues would not damage. It could damage tumor cells and subclinical tumor focal lesions.After researched lots of documents about hyperthermia treatment of tumors with magnetic nanoparticles, analyzed and calculated the high frequency magnetic field theory, referred to design method of induction heating, then put forward design method of high frequency magnetic field generator device for hyperthermia treatment of tumors with magnetic nanoparticles, and developed experimental prototype of alternating magnetic field generator for hyperthermia treatment of tumors with magnetic nanoparticles.PEG-PEI/Fe3O4 nano-magnetic liquid was prepared for hyperthermia treatment of tumors with magnetic nanoparticles by coprecipitation method, and mensurated particle size, Zeta electric potential, X-ray diffraction pattern, IR spectra, magnetization. The results showed that PEG-PEI/Fe3O4 nano-magnetic liquid fit for hyperthermia treatment of tumors with magnetic nanoparticles.The magnetocaloric effect of Fe3O4 nano-magnetic liquid was researched by experimental prototype of alternating magnetic field generator for hyperthermia treatment of tumors with magnetic nanoparticles, and evaluated the parameters of the device. The mathematic model of magnetocaloric effect of nano-magnetic liquid was build. The mathematic model described the relations between the temperature of nano-magnetic liquid under alternating magnetic field, magnetic field intensity and time.Development of experimental prototype of alternating magnetic field generator for hyperthermia treatment of tumors with magnetic nanoparticles put forward new method for device development of hyperthermia treatment of tumors with alternating magnetic field. It showed that hyperthermia treatment of tumors with magnetic nanoparticles was feasible. The works had guidance significance of device design, animal experiments, clinical trial and clinical equipment development. It also provided equipment platform and theoretical foundation for application researches of magnetic nanoparticle. |
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