The Relationship Between ATP-binding Cassette Transporter 1 Gene Polymorphism And The Lipids, The Location And The Size Of Hematoma In Cerebral Hemorrhage

Objective To explore the relationship between the ATP-binding cassette transporter A 1(ABCA1) R219K gene polymorphism and the lipids, the location and the size of hematoma in cerebral hemorrhage.Methods This was a case-controled study, which enrolled 280 cases with cerebral hemorrhage (187 basal ganglia/internal capsule, 56 lobar, 24 brain stem and 13 cerebellum) and 288 healthy controls without CHD and CVD. Polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) was used to determine ABCA1 gene polymorphism.Results The ABCA1 R219K genotype frequencies of healthy controls were R/R33.3%,R/K 48.6% and K/K 18.1%; the ABCA1 R219K genotype distribution in the subjects with cerebral hemorrhage were R/R42.9%,R/K 41.4% and K/K15.7%. There was no significant difference in ABCA1 R219K genotype and allele distribution between all cerebral hemorrhage patients and the healthy controls (P>0.05). Combined the variant gene K together, which was the R/K+K/K genotype, there existed significant difference between cerebral hemorrhage and controls in R/K+K/K genotype (P<0.05). The size of hematoma showed no significant difference among difference genotype in the same location of cerebral hemorrhage frequencies (P>0.05). There was no statistical difference in ABCA1 R219K genotype and allele frequencies between all different locations of recurrent cerebral hemorrhage patients and control group. There was no significant difference in the level of lipids in ABCA1 R219K genotypes (P>0.05). The risk factors of cerebral hemorrhage included the history of hypertension, diabetes, smoking and stroke and high level of fasting blood sugur. The R/K+K/K genotype was possibly the independent protective fator of cerebral hemorrhage, but the P value was 0.047.Conclusion 1.The ABCA1 R219K genotype polymorphism did not impact the lipids demonstrably; 2.The ABCA1 R219K genotype polymorphism did not impact the locations of cerebral hemorrhage demonstrably; 3.The ABCA1 R219K genotype polymorphism did not impact the size of hematoma in cerebral hemorrhage demonstrably; 4.The variant gene carrier R/K+K/K genotype was possibly the independent protective fator of cerebral hemorrhage.