Study On Clinical Characteristics And Risk Factors For New-Onset Diabetes Mellitus After Kidney Transplantation

Objective: To investigate the incidence,clinical characteristics and risk factors for new-onset diabetes mellitus after kidney transplantation (NODAT) .Methods: we studied 308 patients who underwent kidney transplantation in kidney transplantation of Jiangxi Province People's Hospital from January 1994 to May 2008 these patients were not diabetes before operation and their survival are more than 6 months. According to the diagnostic criteria, They are divided into two groups,Analyze all variables that may be related to the development of NODAT, Including age, body mass index (BMI), cholesterol,triglycerides, liver function, positive family history of diabetes, postoperative blood cyclosporin A (CsA) blood concentration, immunodepressant and the acute rejectionResults: 1) After renal transplantation,28 cases occurred NODAT in the 308 patients;the incidenee of NODAT was9.09%.2)There was statistical significance in patient's BMI ,age,cholesterol,triglycerides,liver function between two groups. 3) There was statistical significance in acute rejection,high-dose glucocorticoid,application of FK506 between two groups. 4) It was shown that preoperative fasting blood glucose and family history of diabetes have not obvious effects on its occurrence in this study.Conclusions: 1) the incidence of new-onset diabetes mellitus after kidney transplantation is 9.09% and similar to that reported in literatures. 2) large pre-operative body mass index,abnormal triglyceride,abnormal cholesterol,abnormal liver function,acute rejection,high-dose glucocorticoid,application of FK506 are adjustable risk factors for the development of NODAT. 3) Age is involved in the development of NODAT .4) The timely intervention of the risk factors of adjustable, management and treatment of patients under the new guidelines can reduce the risk of NODAT and improve the quality of life of patients.