Study On Membrane Controlled-release Coated Droppill Of Flavonoids

The sustained released coated droppill of Flavone of Crataeguspinnatif ida Bunge and the self-emulsifying sustained released coated droppill of Puerarin were prepared in this experiment, the influencing factors of releasing of which were investigated.Chosing Flavone of Crataeguspinnatif ida Bunge as modle drug, the methods of UV and HPLC to determine the releasing of sustained released coated droppill of Flavone of Crataeguspinnatif ida Bunge were established.The technology of extracting Flavone of Crataeguspinnatif ida Bunge was Investigated .Used the orthogonal design to get the optimal extracting prescription. Used solid dispersion technology to improve the dissolution of Flavone of Crataeguspinnatif ida Bunge. The major coating material of droppill was coated by EC and EudragitRL/RS.The releasing of droppill was controlled by controlling the amount of EC ,the rate of EudragitRL/RS, the amount of DEP and the thickness of coating.After investigating the effect of single fator ,the optima1 formulation was obtained by uniform design. The releasing of sustained released coated droppills of Flavone of Crataeguspinnatif ida Bunge was to get 85% in12h in vivo.Chosing Puerarin as modle drug, the methods of UV to determine the releasing of self-microemulsifying sustained released coated droppill of Puerarin was established. The kind of oil phase, emulsifier and co-emulsifier was sieved.The rate of emulsifier and co-emulsifier was determined. After making three-phase diagram,the optimal formulation was determined by comparing the area of three-phase diagram.After making the liquid self-microemulsifying emulsion to be solidificated and then to be droppill, the releasing of self-emulsifying sustained released coated droppill of Puerarin was controlled by coating sustained released. The major coating material of droppill was coated by EC .The releasing of droppill was controlled by controlling the amount of DEP and PEG400 and the thickness of coating. After investigating the effect of single fator,the optima1 formulation was obtained by uniform design. The releasing of self-microemulsifying sustained released coated droppill of Puerarin was to get 85% in12h in vivo.