Observation Of The Efficiency And Safety Of Acute Cerebral Infarction Cured With Different Dosage's Rt-PA

Objectives: To discussion the curative effect and security about different dosage's rt-PA (by German Bolingeyingehan Multinational cor- poration production) to treat acute cerebral infarction onset within 6 hours.Methods: We divided the patients with the stroke symptoms (the internal carotid artery system) onset within 6 hours into 2 groups: 1. A group (rt-PA use dosage is 0.7mg/Kg, most large dose is 70 mg): Figures out the integral dose according to rt-PA the 0.7mg/Kg, dissolves in the 100ml physiological saline, 10ml in the first minute in vein pushes the note, in addition the 90ml liquid entered by the 90ml/h speed vein pump, after finishing, used the physiological saline ram; 2. B group: (rt-PA use dosage is 0.9mg/Kg, most large dose is 90 mg): Figures out the integral dose according to rt-PA the 0.9mg/Kg, dissolves in the 100ml physiological saline, usage before. Two groups simultaneously carry on the conventional treatment. We used the modified Rankin scale (mRS) and the Activity of Daily Living Scale (ADL or Barthel Index, BI) at 3 months to be the main curative effect target: mRS (0-1) divides as well as the Barthel index≥95 divides into effectively; and uses the National Institutes of Health Stroke Scale (NIHSS) as the secondary target. The incidence of intracranial hemorrhage within the treatment period and mortality at 3 months were used as the target of the validity and the security. Carries on the data analysis using the SPSS statistics software, to the measurement material with X±S the expression, carries on the T-test; Uses Chi-square examination to the counting material, P values<0.05 has statistics significance. Results:1. Among the 90 patients enrolled, excluded Basilar artery infarction, except those 7 cases of the system, 3 patients as follow-up losers and 5 patients that information were not completed, there were 75 patients participated in the final statistical analysis.2. Two groups can be effective in improving neurological function, two groups 24 hours after treatment and 3 month NIHSS score compared with the pre-treatment significantly differences, but within 24 hours after treatment and three months after the two groups showed no significant difference. 3 months after the prognosis is good (mRS score 0 or 1) were 16 cases of Group A for 47.06%; B group 21 cases, 51.22% for the two groups showed no significant difference. 3 months after the restoration of a satisfactory (Barthel Index≥95) A group of 17 cases were for 50.00%; B group 22 cases, 53.66% for the two groups showed no significant difference. A group of intracranial hemorrhage in three cases for (8.82%), B group of five cases (12.20%); A group of two cases of death (5.88%), B group 3 died (7.32%), three months after the treatment of two groups of intracranial hemorrhage and mortality rates not significantly different.We need to further expand the sample size to discuss the curative effect and security about different dosage's rt-PA (by German Bolingeyingehan Multinational corporation production) to treat acute cerebral infarction onset within 6 hours. Enable the result to be more objective and have the clinical guiding sense.Conclusions:1. It has been confirmed that the clinical curative effect and security of intravenous thrombolysis with rt-PA (0.7mg/Kg) within 6 hours of stroke onset.2. It has been confirmed that the clinical curative effect and security of intravenous thrombolysis with rt-PA (0.9mg/Kg) within 6 hours of stroke onset.3. It will be needed to further increase the sample size to examine China's application of rt-PA treatment of morbidity 6 hours of acute cerebral infarction of the best dose.