Dyslipidemia Features Of Ischemic Heart And Brain Diseases

ObjectiveThe study is for observing the characteristics of blood lipid profile in patients with acute myocardial infarction(AMI) and patients with cerebral infarction(CI),in order to providing evidences for clinical work of ischemic heart and brain diseases.MethodsPatients with acute myocardial infarction(AMI) and patients with cerebral infarction(CI) were reviewed,who were recruited in the neurology department, emergency department and cardiopathy department of our hospital from January 1st 2005 to March 31st 2009.Blood lipid profile of 431 patients with CI, average age(63.19±12.30),237 patients with AMI,average age(61.74±12.58),and 177 healthy common population were used as control,average age(61.32±12.30).They were divided into 3 groups.Plasma triglyceride(TG), total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),non- high density lipoprotein cholesterol(non-HDL-C) levels of various groups of them were compared and analyzed,as well as the ratio of TC/HDL-C and ApoB/ApoAI and the incidence of dyslipoproteinemia.We utilized one-way ANOVA Test in comparison of 3 groups by SPSS. ResultsBetween any two groups,the levels of TG were not significant difference (p＞0.05).The levels of non-HDL-C was significant difference between any two groups(p＜0.05),the CI's higher than the AMI's,the AMI's higher than the normal controls.The levels of Lp(a) was significant difference between any two groups(p＜0.05),the AMI's higher than the CI's,the CI's higher than the normal controls.The levels of TC,LDL-C and Apo B in patients with CI was higher than that in patients with AMI or normal controls,and the difference is significant(p＜0.05).The levels of HDL-C in normal controls was higher than that in CI or AMI group,and the difference is significant(p＜0.05).The levels of ApoAI in AMI group were lower than that in CI group or normal controls,and the difference is significant(p＜0.05).The levels of ApoB/ApoAI in normal controls was lower than that in any group,and the difference is significant (p＜0.05).In CI group or AMI group,differences of TG,TC/HDL-C, APOB/APOAI and Lp(a) between male and female,have not statistical significances(p＞0.05).The levels of TC,non-HDL-c,LDL-C,Apo AI,and Apo B of female in CI group or AMI group,and the difference is significant(p＜0.05). The levels of HDL-c of female in AMI group were higher than these of male,but in CI group the difference isn't significant(p＞0.05).In the AMI group,the incidences of dyslipoproteinemia of HDL-c,TG, LDL-C,TC are 41.8%,42.2%,36.7%,28.7%,27.9%.In the CI group,the incidences of dyslipoproteinemia of HDL-c,LDL-C,TC and TG,are 41.8%,42.2%,36.7%,28.7%,27.9%.Between male and female of any group,the levels of TG,TC/HDL-C, APOB/APOAI,Lp(a) are not significant difference(p＞0.05).Between male and female of any group,the levels of TC,LDL-C,APOB,APOAI,non-HDL-c are significant difference(p＜0.05),the female higher.Conclusion1.In the patients with CI,the main characteristics of blood lipid profile are TC,LDL-c and non-HDL-C,Apo B's elevation.The next is the elevation of TG,the reducing of HDL-C and the elevation of Lp(a).2..In the patients with AMI,the characteristics of blood lipid profile are HDL-C and ApoAl's reducing and the Lp(a)'s elevation.The next is the elevation of TG,LDL-C and TC.3.Lp(a) as one independent arteriosclerosis factor has close relation to AMI.4.After menopause,the levels of arteriosclerosis lipid are higher than these of male patients of the same age.