Research On The Closed-loop Artificial Islet System Modelling & Control Simulation

Diabetes is an endocrine diseases that difficult to cure. The main hazard is its complications, particularly chronic complications. With the improvement of living standards of people, the ageing of the population and the increasing incidence of obesity, the incidence of a rising diabetes situation trend year by year. China's diabetes situation is very severe, prevention and control work is without delay.In this paper, the development of artificial islet was introduced. Artificial islet is an intelligent insulin infusion system in clinical simulation of human physiological insulin secretion in the last 20 years. Artificial islet will be very convenient and effective to control blood glucose in normal or near normal levels in clinical application. The main advantage is the body's stable absorption of insulin so that the drug concentrations in the blood will be stabilized which delaying the complication and development of the diabetes and the blood glucose will be smoothly controlled which reducing the incidence of low blood glucose.In this paper, closed-loop artificial islet is the key content. Closed-loop artificial islet which has the best simulation of the human physiological insulin secretion is a significant improvement to the general artificial islet, it is the best means to control the blood glucose and is the most safe, effective and convenient way in the clinical treatment of diabetes. But the latest reading of the literature found that the current closed-loop artificial islet is not a real closed-loop system in the sense of control theory, and does not truly show the excellent performance of the closed-loop system in the blood glucose control.In this paper, the closed-loop artificial islet system, including human body, is performed a thorough analysis from the perspective of the biological control theory, a precise mathematical model of the whole system is established and the closed-loop control of the blood glucose is achieved in the sense of control theory. The establishment of Closed-loop artificial islet system control theoretical model is conducive to diabetic patients with a more reasonable accuracy digitization treatment. At the same time, the use of advanced control technology for the closed-loop artificial islet system on the comparison of a variety of control strategies shows excellent control performance. Therefore, the introduction of the biological control theory to the closed-loop artificial islet of diabetes treatment device is theoretical innovation once again.