The Effect Of Xionglou Tongmai Decoction Intervention Of PAGT,GGT,ALT,AST In T₂DM Patients

Objective:To explore the effect of Chinese medicine Xionglou Tongmai decoction which was founded on the basis of removing phlegm and blood-stasis together on serum levels of PAGT,GGT,ALT,AST in T₂DM patients with syndrome of phlegm-blood stasis.Methods:140 T₂DM patients with syndrome of phlegm-blood stasis were selected and randomly divided into the treated group(n=97) and the control group(n=43).Patients attended to the education courses for diabetes and were treated with hypoglycemic agent in routine and reasonable diet.To those patients in treated group,Xionglou Tongmai decoction was given additionally with one dose taken twice per day,for a total 14 days' treatment.Assayed serum levels of PAGT,GGT,ALT,AST,FBG and clinical traditional Chinese medicine symptom at the start and the end of the trial respectively.At the same time,some patients also received measurements of their level lipids if possible.Results:1.Serum levels of GGT in the treated group,there was significantly difference compared with that of before treatment(P＜0.05).Serum levels of GGT in the control group,there was no significantly difference compared with that of before treatment(P＞0.05).GGT had no significantly difference between groups after treatment(P＞0.05).The variety of GGT had significant difference between groups(P＜0.05).2.Serum levels of PAGT in the treated group and in the control group,there was no significantly difference compared with that of before treatment(P＞0.05).PAGT had no significantly difference between groups after treatment(P＞0.05).The variety of PAGT had no significant difference between groups(P＞0.05).3.Serum levels of AST,ALT in the treated group and in the control group,there was no significantly difference compared with that of before treatment(P＞0.05).AST,ALT had no significantly difference between groups after treatment(P＞0.05).The variety of AST,ALT had no significant difference between groups(P＞0.05). 4.Serum levels of fasting blood glucose(FBG) decreased in both groups(the treated group: P＜0.01;the control group:P＜0.01),but FBG had no significantly difference between groups after treatment(P＞0.05).The variety of FBG had no significant difference between groups(P＞0.05).5.Serum levels of total cholesterol(TC),triglyceride(TG) decreased in the treated group (TG,TC P＜0.01),but there was no significantly changes in the control group(P＞0.05). Serum levels of APo-a had significantly difference between groups(P＜0.05).but others have no changes.The variety had no significant difference between groups(P＞0.05).6.The disease effective rate was significantly higher in the treated group compare with that in control group(P＜0.05).Conclusions:Xionglou Tongmai decoction which was founded on the basis of removing phlegm and blood-stasis together could obviously lower serum levels of inflammatory cytokines GGT and ameliorate vascular chronic inflammation,and alleviate clinical symptoms of patients.It also could decrease TC,TG,then could resist diabetic vascular injuries.