Clinical Study On Relationship Between TCM Syndrome Differentiation-Type Of Hypertensive Intracerebrial Hemorrhage In Acute Stage And Endothelin And Calcitonin Gene Related Peptide

Objective:To study the relationship among Endothelin,Calcitonin gene related peptide and TCM Syndrome Differentiation-type(TCM-SDT) of Hypertensive Cerebral Hemorrhage(HCH) in acute stage,trying to find some peculiar indexes and leading them to the TCM differentiation of HCH in acute stage.These indexes which make the differentiation more practical provide reliable basis for treatment,besides they can illuminate the distribution regularity of TCM-SDT of Hypertensive intracerebral hemorrhage in acute stage.Methods:80 patients cases of HCH(Within 72 hours).Dividing the patients by differentiation standard and collecting their test results of ET,CGRPand compared with those in 25 healthy subjects in control group.To analyze the distribution regularity of TCM-SDT of HCH and its relationship to the levels of these test results.Results:1.The levels of ET,CGRP in HCH patients are significantly different from those in control group(P＜0.01).2.Donstituent ratio of TCM-SDT of HCH:Syndrome of anemogenous phlegm stasis＞Syndrome of phlegm caloric FU-organ sthenia＞Syndrome of anemogenous pyrophlegm domination＞Syndrome of pathogenic wind-fire trouble supra 3.The level of ET of HCH:Syndrome of anemogenous phlegm stasis＞Syndrome of phlegm caloric FU-organ sthenia＞Syndrome of anemogenous pyrophlegm domination＞Syndrome of pathogenic wind-fire trouble supra,The levels of ET in Syndrome of anemogenous phlegm stasis and Syndrome of phlegm caloric FU-organ sthenia are significantly different from those in Syndrome of anemogenous pyrophlegm domination,Syndrome of pathogenic wind-fire trouble supra(P＜0.01).but The levels of ET in Syndrome of anemogenous phlegm stasis are not significantly different from those in Syndrome of phlegm caloric FU-organ sthenia(P＞0.05).Syndrome of anemogenous pyrophlegm domination are not significantly different from those in Syndrome of pathogenic wind-fire trouble supra(P＞0.05).4.The level of CGRP of HCH:Syndrome of anemogenous phlegm stasis＞Syndrome of phlegm caloric FU-organ sthenia＞Syndrome of anemogenous pyrophlegm domination＞Syndrome of pathogenic wind-fire trouble supra,The levels of CGRP in Syndrome of anemogenous phlegm stasis and Syndrome of phlegm caloric FU-organ sthenia are significantly different from those in Syndrome of anemogenous pyrophlegm domination,Syndrome of pathogenic wind-fire trouble supra(P＜0.01).but The levels of ET in Syndrome of anemogenous phlegm stasis are not significantly different from those in Syndrome of phlegm caloric FU-organ sthenia(P＞0.05).Syndrome of anemogenous pyrophlegm domination are not significantly different from those in Syndrome of pathogenic wind-fire trouble supra(P＞0.05).Conclusion:1.Compared patients who are in acute stage of hypertensive cerebral hemorrhage with the normal,the levels of ET and CGRP are significantly different,suggesting that both ET and CGRP participate in the patho-physiological process of hypertensive intracerebral hemorrhage,the two are closely related.2.Among the different TCM-SDT of HCH,the levels of ET and CGRP increase in varies degrees,Syndrome of anemogenous phlegm stasis and Syndrome of phlegm caloric FU-organ sthenia are the most significant.Syndrome of anemogenous phlegm stasis and Syndrome of phlegm caloric FU-organ sthenia focus on the pathological mechanism of "sputum", "Blood stasis".The study suggests that test of the levels of ET and CGRP can be used to guide for diagnosis of syndrome of phlegm stasis.