| ObjectiveTo observe the clinical effect of on Cronary heart disease(CHD) people with angina,to explore the influence of the capsule to serum lipid and the platelet maximum agglutination,to tell the efficacy and safety of the drug,and to provide the clinical evidence for the treatment of traditional Chinese medicine with Yang Xuan Bi-type agents to angina pectoris.MethodsSixty patients who were hospitalized and out-patiented in 2005.7 -2005.12 in No.1 hospital of Wuhan were divided randomly into two groups.Two groups of patients stopped all Chinese medicine and nitrates 5 days for preparation.Conventional treatments such as calcium antagonists,β-blocker,ACEI,statin drugs to maintain the original volume remained unchanged,and the labor to maintain the status quo remained unchanged,conventional therapy of each group was not changed.The treatment group which contained 30 people took with Boxintong capsule;the control group which contained 30 people took with Suxiaojiuxin pill.The period of treatment was four weeks.At the end of treatment,clinical efficacy,electrocardiogram,blood lipids and maximumplatelet aggregation rate test results were compared between the two groups,data was statistised by(?)±s and tested by T tests.The clinical efficacy was compared by Ridit efficacy analysis,sample rate were compared by X~2 test.Results(1)Comparison of clinical efficacy were:there were 29 cases in treatment group,11 cases(37.93%)was cured,10 cases(34.48%)was effective,6 cases(20.69%) was improved,2 cases(6.90%) was inefficiency,total 93.10%efficiency;there were 28 in control group,4 cases(13.79%) were cured,10 cases(35.71%) were effective: 12 cases(42.86%) were improved,2 cases(7.14%)were inefficiency, and the total efficiency was 92.88%,the two groups compared had no significant difference(P＞0.05).(2)Comparisonof two sets of ECG changes:there were 29 cases of abnormal ECG.12 cases(41.38%)were cured,10 cases(34.48%) were effective,4 cases(13.79%) was improved,3 cases(10.34%)was inefficiency.The total effective rate was 89.29%.There were 28 cases ofabnormal ECG in control group.3cases(10.74%) were cured, 13 cases(46.43%) were effective,10 cases(35.71%) was improved,2 cases(7.14%) was inefficiency,and the total efficiency of 92.59%, the two groups compared had no significant difference(P＞0.05).(3)Comparison of two lipid levels:comparison between the two groups before treatment,no significant difference(P＞0.05),after treatment between the two groups,there are significant differences (P＜0.05);There was a significant difference(P＜0.05).(4)Changes in maximum platelet aggregation rate comparison: after treatment maximum platelet aggregation was significantly decreased,the difference was significant(P＜0.05),boxintong capsule was more effective (5)Detection of security indicators:safety indicators capsule test results showed that no significant adverse drug reaction and toxic side effects,the larger the scope of clinical safety of boxintong capsule.ConclutionBoxintong capsule can be significantly reduced low-density lipoprotein and maximum platelet aggregation rate,increase high-density lipoprotein,and to improve the symptoms of patients with angina pectoris,clinical application safe and effective. |
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