Study On The Compound Azithromycin And Dexamethasone In Situ Forming Eye Gel

Prescription of choice for the design process,select the appropriate accessories to achieve the compound of azithromycin and dexamethasone ophthalmic In situ forming eye gel prescription process and study and evaluate their quality. This product is temperature-sensitive gel,the main polymer materials are Poloxamer,However,the amount of Poloxamer is very large when we use Poloxamer alone.So we consider to use other polymer materials with Poloxamer.To do like this,not only can we reduce the amount of Poloxamer,but also can improve the adhesion of biological materials to delay the release of good results.Orthogonal experimental design of the ratio of polymer materials filter through the gelling temperature test to determine the best ratio of polymer materials,and the best ratio is:15%poloxamer and 0.2%Polycarbophil.To screen the amount of NaCl by testing osmotic pressure of the compound of azithromycin and dexamethasone ophthalmic In situ forming eye gel.According to the sample under the preparation process,we choose the prescription whose osmotic pressure is the most nearest to 300 to determine the amount of NaCl:0.24g with osmotic pressure osmotic pressure meter.We test the effectiveness of antimicrobial preservatives dosage with reference to the effectiveness of the United States Pharmacopoeia antimicrobial test,and it proves that,the amount of preservative benzalkonium chloride:0.003g can achieve the target of effective antibacterial activity of anti-corrosion through antimicrobial effect testing;After the completion of the prescription process,we still require to study the release of prescription and sedimentation volume ratio,to study the release,we need HPLC for the determination. And the goods have two main drugs,It' s not easy to achieve under the same chromatographic conditions,so setting up two sets of chromatographic conditions is required.We need to do two sets of HPLCmethodology.Dexamethasone at a prescription of the design process is dispersed in poloxamer.So it' s necessary to test whether the storage of prescription can happen or not.In the inspection of the quality of prescription, the prescription can fully release within 24 hours by the test of the release,and the release is zero class;Sedimentation volume ratio tests show that the storage of the goods at the basic process of the settlement does not happen.That is, combining the characteristics of gel-type,we set up a reasonable selection of the prescription process,and can effectively control the quality of the target.That type has a good eye gel application,but this new drug delivery Systems research methods and the traditional eye preparations are different.In order to study the safety and effectiveness,the establishment of effective measures to control its quality is necessary.