| Objective:To observe the effect of Compound Decoction Shugan Yangyin huoxue A gifted musicians together to Hashimoto's thyroiditis patients with clinical efficacy, as well as patients with target-related effects of the laboratory, in order to provide a theoretical basis for clinical use.Methods1 Clinical data: Department of clinical data in all cases in October 2006- October 2008 the first hospital in Wuhan City, Hubei Province outpatients, a total of 60 cases, were randomly divided into treatment group 30 cases and 30 cases of the control group. Treatment group and control group of patients with gender, age, course of disease, clinical manifestations, thyroid hormone levels, thyroid antibody levels, goiter, statistical tests, no significant difference, P> 0. 05, comparable.2 The medical method: A two are excellent musicians with 25-75ug, daily orall, treatment group were Decoction Shugan Yangyin huoxue HuoXue therapy, each a day, each time about 150ml, sooner or later take two. Treatment: continuous administration for 1 month a course of treatment, continuous therapy for 3 months. 3 Clinical Observation3.1 The main clinical symptoms: Hashimoto's hypothyroidism: Clinical visible drowsiness, loss of appetite, no sweat, cold, insensitive, indifferent face, pale chlorosis, dry skin, constipation, weak pulse rate symptoms such as slow. Record once every two weeks.3.2 Clinical signs: thyroid size, myxedema, once every two weeks to observe and record.3.3 Related physical and chemical examination: thyroid function: serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH) test to check once every four weeks to check and record the time. Thyroid-associated antibodies: thyroglobul in antibody (TGAb), thyroid microsomal antibody (TPOAb), checked before and after treatment.4 Safety Observation:4.1 Laboratory tests: blood, urine, then conventional; liver and kidney function; separately checked four weeks.4.2 Adverse Reactions: To observe the effect of this drug in patients with any discomfort, combined with blood, liver and kidney function checks to observe the drug has toxic side effects.5 Statistical Methods: Statistical analysis software SPSS14. 0 calculation. All measurement data with(X|-)±S (mean±standard deviation) that the use of t test; count data using X~2 test; Level Ridit analysis of data used.Results:1 Comparison of efficacy of two syndromes: the total effective rate in treatment group 93. 3%. Has the efficiency of the control group 73. 3% of the total. By Ridit analysis, the treatment group compared with the control group were significantly different, P <0. 05.2 Two aspects of traditional Chinese medicine symptom score compared by t test, treatment and control groups both before and after treatment to improve symptoms, but the treatment group to improve the neck swelling, edema and other features there is a very significant difference, P <0. 01.3 Comparison of thyroid function before and after treatment, treatment group and control group can increase the level of thyroid hormone to reduce the level of thyroid stimulating hormone, by the t test, treatment and control groups before and after treatment were significantly different, P <0. 05, treatment group comparison no significant difference, P> 0.05.4 Goiter before and after treatment comparison, the test control group, there is difference before and after treatment, P <0.05, treatment group before and after treatment were significantly different, P <0. 01, comparison between treatment group differences, P <0. 05.5 To improve the immune target, the two groups before treatment TGAb, TPOAb showed no statistical significance,P>0. 05, after treatment, there is statistical significance,P<0. 01, control group after treatment was not significant P>0. 05, treatment After the difference between groups with the most significant, P<0. 01,effect of treatment group was superior to the control group.6 Two sets of adverse reactions after treatment: the treatment group and control group are aware of any adverse reactions.Conclusion: Decoction Shugan Yangyin huoxue A gifted musicians combined treatment is effective for Hashimoto's thyroiditis, can effectively control the symptoms of Hashimoto's thyroiditis, can significantly reduce the goiter, particularly in immunology target significant role to improve. In the medication process, liver, kidney function and blood had no significant effect, played a traditional Chinese and western medicine advantages are a safe and effective treatment, worthy to be popularized. |
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