Analysis Of The Clinical And Laboratory Features And The Prognosis Of Acute Leukemia With Complex Karyotypes Aberrations

ObjectiveTo analyze the clinical and laboratory features of complex chromosome aberrations AL and assess the prognosis.MethodsIn a retrospective follow-up study from 2005.3～2007.11,27 AL patients with complex chromosome were investigated,other 27 AL patients with none complex chromosome patients were the control group.AL with complex karyotypes aberrations werc diagnosed with morphological,immunological,cytogenetic classification and molecular biology.Then we assessed the prognosis.ResultsThere was no significate difference at clinical presentation and laboratory features between AL patients with complex chromosome aberrations and the control group during the samc period(p＞0.05).Cell CD₃₄ was expressed in 74.1%of the AL patients with complex chromosome aberrations,signifiantlly higher than the control group (37.4%)(p＜0.01 ),and the CD₃₄⁺ AL patients with complex chromosomc showed a lower CR rate than CD₃₄^- cases(p＜0.05 ).Using Kaplan-Meier analysis,the median survive time of AL patients with complex chromosome was only 4 months,significantly shorter than the control group.there was no signification difference between AML and ALL patients with complex chromosome aberrations at CR rate and the survive time.ConclusionsAL with complex chromosome aberrations had a poor treatment outcome and short survival.These patients should be considered as a unique entity and be separated from those with a noncomplex adverse cytogenetic change.Exploring the underlying mechanisms of leukemogenesis could improve the therapeutic outcome for this group of patients.CD₃₄⁺may be one of the reasons to explain why the poor prognosis of AL patients with complex chromosome,but it is only a presumption,we need to search next.