Clinical Analysis Of 43 Langerhans Cell Histiocytosis Cases

Objective:Langerhans cell histiocytosis is a rare proliferative disease of pathological langerhans cells.Clinical manifestations vary according to the organs involved.This study aimed at analyzing the clinical and prognostic features of the disease by studying of 43 LCH cases of Zhejiang Children's Hospital.Methods:Collect of the clinical manifestations,laboratory findings were performed according to the hospital database of the hospitalized patients.The follow up materials were obtained via telephones of 43 LCH patients diagnosed during Oct.2003 and Jan. 2009 in our hospital.The incidence of different systems,organs or tissues affected as well as auxiliary examination results and prognostic features were investigated.Results:Male and younger individuals were found to be more likely to develop the disease.A considerable number of patients experienced the past or current viral infection.The risk of bacteria infection was also higher than general population. Furthermore,immune deficiency was detected in some of the patients by flow cytometric technology.The hematological system,skeletal system,skin,mucosal and liver were the most commonly attacked organs.Comparing with stageâ… andâ…¡patients according to Lavin-Osband criteria,those in stageâ…¢orâ…£had worse prognosis.Conclusions:Langerhans cell histiocytosis can attract many organs of the human body containing reticuloendothelium tissue and cause various clinical manifestations. Etiology and pathogenesis of the disease is still unknown.A thorough physical accessory examination is vital in the diagnostic process.Lavin-osband stageâ… andâ…¡ patients will experience a better prognosis.