Infiltrating Ductal Cancer Of Breast: Correlation Between Ultrasonographic Features And Pathologic Prognostic Predictions

Objective To probe the relationship between the appearance on ultrasonic sign and Pathologic Prognostic Predictions estrogen receptor(ER), progesterone receptor(PR) and Human epidermal growth factor receptor 2(C-erbB-2,HER2/neu) in infiltrating ductal carcinoma of breast(IDC),and evaluate the possibility of predicting the expression of ER,PR and C-erbB-2 in IDC preoperation by means of ultrasonograph.Methods 207 patients with IDC confirmed pathologically were involved in this study.ER,PR and C-erbB-2 expression of the mastectomy specimens was determined with immunohistochemical staining technique.The correlation between the ultrasonographic features and ER,PR and C-erbB-2 positive expression was analyzed.Resultsâ‘ Of 207 cases,the ER positive rate is 57.97%(120/207),ER positive rate in lesions with spicule sign or posterior shadowing of the ultrasonography was higher than that in lesions without the certain ultrasonographic features(P < 0.05).micro calcifications of the ultrasonography,size of breast tumor,Axillary lymphnodes metastasis,CDFI and Menopausal state have not statistically significant difference with ER Positive expression(P>0.05).â‘¡the PR positive rate is 76.81%(159/207), PR positive rate in lesions without Axillary lymphnodes metastasis was higher than that in lesions with Axillary lymphnodes metastasis(P<0.05).spicule sign,posterior shadowing and micro calcifications of the ultrasonography,size of breast tumor,CDFI,Menopausal state have not statistically significant difference with PR Positive expression(P>0.05).â‘¢Of 207 cases,the C-erbB-2 over expressive rate is 29.95%(62/207),and the C-erbB-2 over expressive rate in lesions with the micro calcifications of the ultrasonography and post-menopause patients was higher than that in lesions without the micro calcifications and before-menopause patients(P<0.05).spicule sign,posterior shadowing of the ultrasonography,size of breast tumor,CDFI and Axillary lymphnodes metastasis have not statistically significant difference with C-erbB-2 Positive expression(P>0.05).Conclusions The spicule sign,posterior shadowing of the ultrasonography showed a certain correlation with ER expression in patients with IDC,without Axillary lymphnodes metastasis correlation with PR;while the micro calcifications,post-menopause patients showed a certain correlation with C-erbB-2 over expression.