Measurement Of Cerebral Blood Flow And Clinical Analysis At Acute Phase In 31 Patients With Intracerebral Hemorrhage

Objective:To observe cerebral ischemic or infarction at acute phase in patients with intracerebral hemorrhage so as to provide scientific evidences for new therapeutic ways to intracerebral hemorrhage.Methods:(1) The 31 cases of intracerebral hemorrhage was in hospital from year 2006 to 2008,between 40-80 years,regardless of sexage,excluding the patients with disease in blood system,intracerebral hemorrhage of the youth and arteriovenous malformation of brain(AVM),subarachnoid hemorrhage(SAH),intracerebral hemorrhage after cerebral infarction,and with severe cardiac insufficiency,liver and renal failure,severe infection and gastrointestinal hemorrhage.(2)The 31 cases were divided into two groups at random by the time of in hospital:one group is control,the 12cases of intracerebral hemorrhage were treated by conventional ways:another group is therapeutic group:thel9 cases of intracerebral hemorrhage were intraveners injected Injection naloxon(4.0mg+N.S 250ml iv drop Qd)and naoxuekang tablets(3# Tid po)besides conventional treatment.all patients were observed with CT and single-photon emission CT(SPECT) at the first day in hospital and the fourteenth day after treatment.(3) we can observe the volume of hemotoma and perilesional edema and cerebral ischemic or cerebral infarction measured by CT scan;SPECT were performed to ensure regional cerebral blood flow(rCBF),the method of region of interesting was used to measue the uptake counts in the core of hematoma frontal or parietal region around the lesion and their contralateral mirror regions respectively,and calculation the ratio of uptake counts(R) with 9 pixel ring.it is abnormal if R<0.9 or R> 1.1. (4)measurement data was expressed as mean±SD,by t test,it is signicant differences when P＜0.05.Result:(1) the volume of hematoma and perilesional edema and blood pressure of the patients in hospital between the therapeutic group and the control group is not significant differences(P＞0.5).(2)The 31 cases were observed with SPECT within 3 days in hospital.There is primary ischemic focus volume,regional cerebral blood flow(rCBF) decreased in other areas in brain besides the core of hematoma and frontal or parietal region around the lession.The ratio of uptake counts(R) between two groups is not significant differences(P＞0.05).(3)The volume of hematoma and perilessional edema of the patients in the therapeutic group decreased significantly compared with that of the control group after 14 days of treatment,which is significant differences(P＜0.05).(4) After 14 days treatment,the ratio of uptake counts around hematoma and other areas in brain of the patients in the therapeutic group is increased significantly compared with that of the control group and regional cerebral blood flow is increased significantly(P＜0.05).Conclusion:(1) There is other ischemic areas besides hematoma and around hematoma at acute phase in patients with cerebral hemorrhage.(2) The useage of drug in acute phase of in patients with intracerebral hemorrhage can promote the absorbtion of hemotoma,abate perilessional edema and increase regional cerebral blood flow(rCBF),arrived one aim to one therapy way to different disease,and there was no cases of hemorrhage again.