| Liver fibrosis is the concept of a pathology that liver tissue extracellular matrix(ECM) components of the excessive proliferation and abnormal deposition,resulting in liver structure or(and) the pathological changes of dysfunction,can cause liver dysfunction and portal hypertension, such as.Anti-liver fibrosis in TCM research mainly in the basic understanding of the basis of pathogenesis for Chinese herbal compound(the experience side, the classical side),single herbs,explore effective monomer component or components to start,a large number of studies confirmed the anti-Chinese fibrosis of effectiveness.In order to further clarify the law Yiqihuoxue the effectiveness of the treatment of liver fibrosis and Yiqihuoxue other proprietary Chinese side than the existence of the treatment of liver fibrosis, we carried out treatment of hepatitis B Yiqihuoxue clinical study of liver fibrosis.Objective:By working with compound Fufangbiejiaruanganpian comparison clearly Yiqihuoxue Treatment of hepatitis B liver fibrosis have a better effect.Method:In accordance with the random control principle,in accordance with the standard 60 cases of selected cases,treatment group,30 cases of the control group.Treatment group to the experience of Professor Xiong Wensheng Yiqihuoxue side,the control group to the compound Fufangbiejiaruanganpian,treatment before and three months after the treatment of signs and symptoms observed in patients with traditional Chinese medicine(and quantify the points),serum liver fibrosis markers,liver function indicators,the performance of ultrasound imaging of liver and spleen.Results:①The two groups of patients before and after treatment of TCM symptoms and signs compared to improve the situation:The total effective rate was 90.00 percent,while the control group to 60.00%efficient,the treatment group than the control group,the total effective rate between the two groups, P＜0.05.②two groups of patients with liver function before and after changes: After treatment,liver function indicators were significantly improved(P＜0.01),after treatment than the control group also improved significantly (P＜0.01),but better than the control treatment group group,(P＜0.01-0.05).③two patients with changes in serum liver fibrosis markers:the treatment group indicator in the treatment of liver fibrosis decreased after(P＜0.01), the control group in the treatment of hepatic fibrosis also decreased after (P＜0.01) However,the treatment group than the control group(P＜0.05).④the two groups before and after treatment in patients with changes in liver and spleen ultrasonography:treatment group,portal vein diameter,spleen than the thickness of pre-treatment to improve(P＜0.01);control group,the portal vein diameter,spleen than the thickness of pre-treatment to improve(P＜0.01). The treatment group compared with the control group no significant difference (P＞0.05).The two groups before and after treatment in patients with liver and spleen ultrasound level changes:by rank sum test after treatment,liver and spleen ultrasound to improve the level of no significant difference(P＞0.05),the control group level after treatment to improve the liver and spleen ultrasound was no significant difference(P＞0.05).⑤integrated the two groups of patients before and after treatment effects:The total effective rate was 86.67%,while the control group to 60.00%efficient,the treatment group than the control group,the total effective rate between the two groups comparison P＜0.05.Conclusion:Yiqihuoxue good to be able to alleviate clinical symptoms, improve liver function.Yiqihuoxue can inhibit HSC activation,value-added, reducing the metabolism of collagen,inhibit hepatic sinusoid capillarization in order to prevent degeneration and necrosis of liver cells and liver alterations of connective tissue,and reduce liver fibrosis.Yiqihuoxue B-side to improve the results. |
PDF Full Text Request