Study On The Thermodynamic Properties For Solid Dispersion Of Silybin And Quercetin

Silybin and Quercetin are mainly hydrophobic organic compounds. Solid dispersion technology can improve the dissolution rate of hydrophobic drugs. Thermodynamic properties of solid dispersions of silybin and quercetin were studied in this work. It included:1. Solid dispersions of silybin with Poloxamer188 was prepared by fusion-cooling method. In this work, the thermodynamic properties of mixture of silybin + poloxamer 188 were determined. One interest is the study on the possible effect of poloxamer 188 on reducing the melting temperature of silybin + Poloxamer188 solid dispersions. The melting temperature (Tfus) and the enthalpy of fusion,ΔfusH, were measured by differential scanning calorimetry (DSC). The phase diagram and the enthalpy diagram were constructed from experimental data. The data were fitted to the Flory–Huggins model. FT-IR spectroscopy and powder X-ray diffraction were performed to elucidate the structure and possible drug–carrier interactions.2. Solid dispersion of PEG 6000 with quercetin was prepared by fusion-cooling method. The T-wt% andΔfusHw-wt% diagrams were constructed by DSC method. The melting temperature (Tfus) and the enthalpy of fusion,ΔfusH, were measured by differential scanning calorimetry (DSC). The phase diagram and the enthalpy diagram were constructed from experimental data. FT-IR spectroscopy and powder X-ray diffraction were performed to elucidate the structure and possible drug–carrier interactions.3. Solid dispersion of quercetin with Poloxamer 188 was prepared by fusion-cooling method. The T-wt% andΔfusHw-wt% diagrams were constructed by DSC method. The melting temperature (Tfus) and the enthalpy of fusion,ΔfusH, were measured by differential scanning calorimetry (DSC). The phase diagram and the enthalpy diagram were constructed from experimental data. FT-IR spectroscopy and powder X-ray diffraction were performed to elucidate the structure and possible drug–carrier interactions.4.The heat capacity of the system of Sodium cholate + Silybin were determined by DSC.