The Hospitalization-based Investigation And Analysis About Condition And EGFR On CKD Subjects

Part1:The Hospitalization-based investigation and analysis about condition on CKD subjectsObjects: To find out the nutrition condition and influence factors of in-patient's who were taken bad by chronic kidney disease. Methods: Analyze 402 in hospital chronic kidney disease patients' correlation among body mass index (BMI) and serum albumin, various components of blood fats, hemoglobin; compare the different BMI patients' difference with each clinical chemistry targets to know about whether they have statistical significance. Results: the significant correlation was found only between 402 patients' BMI and HB, ALB, TP, TG, TC, LDL-C (P<0.05). The odds ratio computed: HB, ALB, TP, TC, HDL, APOB are smaller than 1, TG, LDL, APOA1 are bigger than 1. When hemoglobin,creatinine,cystatin C and eGFR are compared among these 291 chronic kidney disease persons,the results come out: all the four have no difference between nutrition and malnutrition patients. Overweight and obesity ones have lower creatinine,cystatin C and higher hemoglobin,eGFR than not only nutrition but also malnutrition ones. Obesity patients' hemoglobin and eGFR are higher than overweight'. When patients are divided into nutrition and malnutrition, their creatinine and eGFR have no difference, but malnutrition ones have higher cystatin C and lower hemoglobin. Conclusions: HB, ALB, TP, TC, HDL, APOB are protective factors of chronic kidney disease patients' nutrition, but TG, LDL, APOA1 are the dangerous factors. Then in which hemoglobin relates to nutrition closely. In these hospitalized CKD suffers mainly proceeding from hypertension, diabetes mellitus as well as from the chronic renal glomerular nephritis, overweight and obese patients, in which overweight and the obese patients have lower creatinine,cystatin C and higher hemoglobin,eGFR than nutrition and malnutrition ones. It maybe caused by the high filtration,but indicates that better nutrition may lead to better renal function. Part2:The evaluation and investigation of CKD patientsObjects: The discussion and evaluation of eGFR about CKD patients. Methods: Use the abbreviated MDRD equation, the Cockcroft-Gault equation and the cystatin-C to estimate 292 CKD patients' glomerular filtration rate (GFR), and acquire the correlation among these different methods used to estimate glomerular filtration rate.Results: 292 CKD patients on CKD1-5 stages have the significant difference between the glomerular filtration rate estimated by the abbreviated MDRD and the Cockcroft-Gault equation (P<0.05). The CKD1 stage and the CKD3 stage GFR estimated by the abbreviated MDRD equation and cystatin-C have the significant difference (p<0.05), neither the CKD2 stage nor the statistical 4-5 stages have significant difference (P>0.05). The chronic kidney disease (CKD) patients according to abbreviated MDRD equation by stages 1-5 issued by the Cockcroft-Gault (CG) equation and GFR cystatin-C computed have the statistical significance (P<0.05). Conclusions: Although many kinds of methods cannot estimate glomerular filtration rate accurately, but still have their significance.