Experimental Study Of Carbomer Glaucoma Model In Rabbits By Injecting Different Location In Anterior Chamber

Objective: To evaluate the effect of carbomer glaucoma model in rabbits by injecting different location in anterior chamber, to investigate the best injection site.Methods: Twenty rabbits were divided into two groups: groupⅠandⅡ.The right eyes are model eyes, injecting slowly the pupil center in anterior chamber (Ⅰ) and injecting the perimeter in anterior chamber(Ⅱ) to induce carbomer glaucoma.The left eyes injecting NS in anterior chamber as control. The intraocular pressure (IOP) was monitored with a Schiotz tonometer three days prior to injection and 2 times per day after injection. The basic IOP in every group served as control .After 8 weeks, the results were studied.The optic disk and the thickness of retina were observed and measured.Results: The mean IOP levels were 27.2±1.2mmHg,sustained 25～53 days, and 39.6±2.4 mmHg, 22～28 days in groupⅠandⅡ.The cup of the optic disk was changed significantly.The retinal nerve fibre layer were thinning in groupⅠandⅡ.And there was significant difference between twe models.Conclusion: Experimental glaucoma model induced by carbomer is easy to be carried out.And the method by injecting slowly the pupil center in anterior chamber is more effective than the perimeter in anterior chamber.