Postoperative Analgesia Effects Of Epidural Ropivacaine Plus Nefopam In Patients Undergone TURP

Objective To evaluate the postoperative analgesia efficacy of epidural ropivacaine plus nefopam in patients undergone transurethral resection of prostate.Methods 60 cases ASA physical status I or II patients undergone transurethral resection of prostate with epidural anesthesia who requested postoperative analgesia were assigned to one of three groups according to minimization methods: ropivacaine plus nefopam group, ropivacaine plus fentanyl group and ropivacaine group. The ropivacaine plus nefopam group received a postoperative analgesia with epidural 0.2% ropivacaine plus nefopam 0.4mg/ml. The ropivacaine plus fentanyl group received a postoperative analgesia with epidural 0.2% ropivacaine plus fentanyl 2μg/ml. The ropivavaine group received a postoperative analgesia with epidural 0.2% ropivacaine. The intensity of pain, the intensity of sedation, and the side effects were recorded with double-blind method.Results The three groups were comparable in regard to age, height, body weight and minutes of operation. Three were no significant differences in VAS score between the ropivacaine plus nefopam group and the ropivacaine plus fentanyl group, but patients in the two groups both had lower VAS scores at 2,4,8,24 and 48 hours than those in ropivacaine group. RSS scores were higher in the ropivacine plus nefopam group than in ropivacaine plus fentanyl group at 4 and 8 hours. There were no significant differences in the adverse between the three groups.Conclusion Epidural analgesia with 0.2% ropivacaine plus nefopam 0.4mg/ml provides excellent postoperative analgesia effect for patients undergone transurethral resection of prostate.