| Objectives:To evaluate the therapeutic effects of Chinese herbal medicine by Shenqi Hua Yu Fang(a decoction for supplying Qi and transforming stasis accordding to TCM)with TACE in the treatment of Hepatocellular Carcinoma.We carried out a prospective random trial by observing 40 primary liver cancer patients treated by the Chinese herbal medicine and TACE.And to observe the mechanism on the decation of inhibitting the liver cancer.Methods:(1) The experimental parts-50 Kunming mice were randomly divided into 5 group (saline group,cyclophosphamide group,Shenqi Hua Yu Fang high-dose group, the middle dose group,low-dose group),with 10 mice per group.,0.2ml H22 tumor cell suspension was inoculated in the right axillary(concentration of 1×10~7/ml),after 24 hours,the mice were treated respectively by saline for intragastric administration,Cyclophosphamide for abdominal cavity injection, Shenqi Hua Yu Fang for intragastric administration daily.14 days later,the tumor size,the thymus index,spleen index,inhibition rate,and expression of VEGF by immunohistochemical detection of tumor tissue were observed. (2) The clinical parts--40 primary liver cancer patients were randomized into two groups:treatment group and controlled group,with 20 patients in each group.The treatment group has been given Shenqi Hua Yu Fang one day post TACE, combined with some western medicine for symptom relief when necessary.The controlled group has been given western medicine only.Then we analyzed the degree and duration of Hepatocellular Carcinoma post-chemoembolization Syndrome,alleviation of clinical symptoms,tumor response rate,improvement of KPS,side effects of TACE and hepatic function. Results:(1) The experimental parts-- The rate of tumor suppression,the thymus index, spleen index were increased,VEGF-positive rate was decresed in the high dose of Shenqi Hua Yu Fang.(2) The clinical parts①There were significant differences between the treatment group and the controlled group in Hepatocellular Carcinoma post-chemoembolization Syndrome such as fever,pain,nausea and vomiting.There were also significant differences in the degree of adverse effect of TACE,such as anemia and leucocytopenia.②There were significant differences between the treatment group and controlled group on the improvement of body common conditions.It shows that the treatment group is better than the controlled group in improvement of common conditions.③There were significant differences between the treatment group and the controlled group in AST,ALT,GGT and TB of blood serum one and two weeks post TACE.but these datas in the treatment group were lower than the controlled group,P＜0.05.It showed that Shenqi Hua Yu Fang can relieve the impairment of Hepatic functions post TACE.④There were significant differences between the treatment group and the controlled group in improving clinical symptoms.It shows that the treatment group is better than controlled group in improving clinical symptoms.⑤In the changes of tumor size,the treatment group has no significant difference,p＞0.05 as compared with the controlled group.Conclusions:Shenqi Hua Yu Fang is more effective,compared with western medicine only,on treating Hepatocellular Carcinoma post-Cbemoembolization Syndrome,as well as improving common conditions,Hepatic functions and clinical symptoms.Shenqi Hua Yu Fang could raise the H22 tumor-bearing mice thymus and spleen indexes,and enhance immune function in mice and reduce VEGF expression in tumor tissues. |
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