The Study On The Multiple Factor Analysis Of Phlegm Blood Stasis Syndrome Of Coronary Heart Disease

Objective To study dependablity of the multiple factor and phlegm blood stasis syndrome(PBSS) of coronary heart disease(CHD),to explore the substance of the objective evidence of Phlegm and blood stasis of coronary heart disease, to provide clues and evidence for the research and decision for clinicalMethod To Collect data of in-patient cases of cardiovascular endemic area in First Affiliated Hospital Guangzhou University of Traditional Chinese Medicine from January 2008 to March of 2009,A total of 163 cases is selected,which be divided into in group of PBSS(87 cases) and group of nonphlegm and blood stasis syndrome(NPBSS)(48 cases),And the normal group(28 cases),to collection completely information of cases,to establish of database management with software packages SPSS17.0,For count data,using chi-square test,Data for between each two groups,should be compared with chi-square partitioning;the measurement data,which between the two groups was compared using T test,and which for three sets of data wan used one-way ANOVA.if there was a significant difference,for Data for between each two groups,should be carried on the multiple examinations.According to each observation target evaluation table,all data was carried on Binary the logistic regression analysis.Then we can obtain the regression equation,the regression model should be carried on the likelihood ratio examination,and be evaluated for model forecast effect.Result1.The Phlegm and blood stasis is the main Syndrome of CHD.In patient of CHD, the phlegm stasis tiescard account for 37.0%mutually,the stasis accounts card for 15.6%,the phlegm card accounts for 11.9%,the non-phlegm stasis card accounts for 35.5%.2.Three groups of sexes and age structure were non-significance difference (P＞0.05).coronary disease phlegm stasis group's body weight index was higher compared with other two groups.The data was compared between the group of PBSS with the normal group,and group of PBSS with the group of NPBSS,the two P value is smaller than 0.05.The results have the significance difference.3.For hypertension medical history,diabetes medical history,blood fats unusual history,the result has the significance difference(P＜0.05) between group of PBSS of CHD with the normal group,and group of PBSS of CHD compares with the normal group.4.For hypertension medical history,blood fats unusual history,the result has the significance difference(P＜0.05) between group of PBSS of CHD with the group of nPBSS of CHD.and has no significance difference for diabetes medical history.5.The group of PBSS of CHD has the significance difference with group of NPBSS of CHD in aspect of symptom scoring comparison(P＜0.05).The group of PBSS scoring is higher.6.The results of three group of comparison have not the significance difference(P＞0.05),in comparison in white blood cell total,neutral granular cell percentage,empty stomach blood sugar and meal,blood sugar.7.The comparison between group of PBSS of CHD with the normal group in aspect of the Level of CRP,TNF,IL-6,MMP-9,SCD40L and ICAM-1 was different obviously (P＜0.05),which between group of PBSS of CHD with group of NPBSS of CHD had no significance difference in aspect of the Level of CRP,TNF,IL-6,SCD40L and ICAM-18.The result by comparison group of PBSS of CHD with t group of NPBSS of CHD in the count of crown arteries which have pathological change had the significance difference(P＜0.05).9.The twenty-sixfactors related with phlegm stasis card of coronary disease were carried on the Binary Logistic regression analysis,then the regression equation is obtains,that is of the phlegm stasis of cardoronary disease P =1/1+e^{-(-19.213+1.051×history of blood fat abnormality +2.226×symptom sores +0.740×BMI +1.215×TC+1.092×TG+0.672×CRP+2.182×IL-6+2.851×SCD40L+1.918×ICAM-1+0.803×count of pathological crown arteries)} The P value for likelihood ratios to examine of all parts in the process of regression analysis was smaller than 0.05.The overall rate of accuracy to predicted by the regression equation reached 94.0%.Conclusion Phlegm and blood stasis is the main Syndrome of CHD.In research to its hazard factors,the body weight index,hypertension and the blood fats are exceptionally closed with group of PBSS of CHD.Symptom scoring of group for PBSS is higher.Coronary artery pathological change of PBSS is by multi-pathological changes primarily,which coronary artery's pathological change degree is heavier.The morbility of PBSS of CHD has closed relationship with the rised level of TC,LDL in blood fats four items.PBSS of CHD has closed relationship with the level of CRP,TNF,IL-6,SCD40L,ICAM-1 in Inflammation factorsHorizontal elevation of that six indexes has the important influence with the PBSS of CHD.The final Binary Logistic regression equation for PBSS of CHDis: P=1/1+e^{-(-19.213+1.051×history of blood fat abnormality+2.226×symptom sores +0.740×BMI +1.215×TC+1.092×TG+0.672×CRP+2.182×IL-6+2.851×SCD40L+1.918×ICAM-1+0.803×count.of pathological crown arteries)} The overall rate of accuracy to predicted by the regression equation reached 94.0%.Which forecast effect is good.