Serum Inhibin B,Insulin-like Growth Factor-I Determined On Polycystic Ovary Syndrome Patients And Their Significance

The polycystic ovary syndrome is one kind is taken bad much because of the nature, the clinical manifestation assumes the polymorphism endocrine syndrome, mainly take Menstrual irregularities, the long-enduring ovulation barrier, Hyperandrogenism, the Insulin resistance, Obesity and the ovary multi-pouches as the clinical manifestation, is causes the child-bearing age woman to ovulate exceptionally and the sterile common disease.In recent years studied discovered that PCOS the morbidity besides a classics hypothalamic pituitary gland ovary axis various links adjustment disorder, in ovary's multi-factor governing system was also possible and the PCOS morbidity related, and played the leading role. The inhibin with the insulin-like growth factor is in the ovary in the governing system the important factor, is also at the initial stage at present about these two kind of factor's research, has become the hot spot which the domestic and foreign scholars study. This research establishment in the reference massive reference and summarizes in the predecessor empirical base, is for the purpose of comparing same time the PCOS sterile patient with non-PCOS sterile patient INHB, IGF-I and the sex hormone level, analyzes it with the PCOS relevance, discusses it the inner link which is taken bad with the PCOS patient, then studies the PCOS sterile mechanism as well as provides certain theory basis for the clinical diagnosis and the choice reasonable therapeutic schedule.Methods: Chooses August, 2008 to receive a medical examination to December, 2008 in the first hospital of Jilin University, the second hospital of Jilin University, China and Japan union hospital of Jilin University PCOS patient 40 examples, the age is 25-35 years old. The PCOS diagnosis acts according to the 7th edition of obstetrics and gynecology the diagnosis standard: (1) ovulation thinly or does not have the ovulation (2) hyperandrogenism (3) ovary multi-pouches change: Supersonic prompt one side either two-sided ovary diameter 2-9mm graafian follicle≥12, increases with (or) the ovary volume≥10ml. in the (4)three item conforms to two items to eliminate other hyperandrogenism cause of disease abreast in row, congenital adrenal cortex proliferation, secretion androgen tumor, cushing syndrome.This research chooses the sterile patient 20 examples which receives a medical examination same time to take the control group in addition (sterile reason for oviduct factor or the groom's family factor, menstrual cycle is normal, laboratory examination sex hormone level is normal, age 25-30 years old). Some menstruations in the menstrual cycle 3rd day, menopause in random one day, control group in a menstrual cycle 2~5 day of empty stomach, about 8:00 am the empty stomach pulls out the venous blood, the separation blood serum sets at - 20℃the preservation.Use Elisa to determine sterility patient who 40 example PCOS patient (the PCOS group), 20 examples receives a medical examination same time (control group, menstrual cycle is normal, sterile reason for immunity factor or oviduct factor) INHB, the IGF-I level, emits the immunization to determine the hormone level separately.Results: 1,40 example PCOS patient's LH, the T level elevates obviously, had already surpassed the menstrual cycle various times normal value, and the LH/FSH ratio increases.2,20 example control group sex hormone is located at menstrual cycle various times in the normal range.3,IGF-I, INHB, LH, T compare in the PCOS group and the control group elevate obviously, the difference has the significance (P<0.05)。4,E2 compares in the PCOS group and the control group elevates not remarkable difference (P>0.05), FSH compares in the PCOS group and the control group reduces also not remarkable difference (P>0.05), but the LH/FSH ratio is bigger than 3, PRL compares in the PCOS group and the control group reduces not remarkable difference (P>0.05).Conclusion: 1,The blood serum FSH level is somewhat low, the LH level elevates, the LH/FSH ratio increases, the T level elevates, the estrogen elevates, the estradiol elevates mildly or does not elevate, in the early follicular phase level is the PCOS main endocrine characteristic constantly.2,PCOS the patient foundation blood serum INHB level and the normal control group compared obviously elevate, prompt INHB possibly to participate in the PCOS morbidity pathology physiological process, examined the INHB level, possibly was helpful to the PCOS diagnosis.3,PCOS the patient foundation blood serum IGF-I level and the normal control group compared obviously elevate, prompt IGF-I possibly to participate in the PCOS morbidity pathology physiological process, examined the IGF-I level, possibly was helpful to the PCOS diagnosis.4,IGF-I induces INHB the production, INHB in turn may expand the IGF-I effect, the two promote mutually, when PCOS forms the hyperandrogenism and the ovulation barrier, thus causes in the PCOS forming process to play the vital role, fellowship pathology physiological process.5,IGF-I has the direct production hyperandrogenism function, reduces PCOS patient blood serum IGF-I the level, blocks IGF-I the function way, regarding opens the PCOS new treatment way possibly to have the vital significance.6,The extrapolation reduces INHB and the IGF-I level, blocks INHB and the IGF-I function, will become treats PCOS the new method, will determine INHB and the IGF-I level will be helpful in appraises PCOS the curative effect and the prognosis.