The Effects Study Of Ventilation In The Acute Respiratory Distress Syndrome Canine Model With Pumpless Extracorporeal Lung Assist

The Effects of Pumpless Extracorporeal Lung Assist on Hemodynamics in The Canine Model with ARDSObjective: To find a safe shunt of cardiac output of pumpless extracorporeal lung assist (pECLA) in the canine model with acute respiratory distress syndrom (ARDS).Methods: Oleic acid was infused in canine vein for building ARDS model. Twelve hybrid canines with ARDS were randomized to two groups, and were connected to pumpless extracorporeal lung assist. In group A, the shunt was 25%, 20%, 15%, 10% in turn. In group B, the shunt was 10%, 15%, 20%, 25% in turn. All shunts were continuous for 1 hour. The artery pressure, heart rate and pulmonary artery pressure were recorded in each shunt end before the next shunt befinning.Result: There was no significant variance on blood pressure, heart rate and pulmonary pressure (P>0.05) .Conclusion: There is no overt disturbance in the hemodynamics in 25% shunt of cardiac output in the acute respiratory distress syndrome canine model with pumpless extracorporeal lung assistance . The Effects Study of support in the acute respiratory distress syndrome canine model with pumpless extracorporeal lung assistObjective: To study the effect of support in the acute respiratory distress syndrome canine model with pumpless extracorporeal lung assist.Methods: Six models of the last champer were used. After building the ARDS model with maximum shunt of cardiac for 0.5 hours, fraction of inspired oxygen was adjusted basing on the PaO₂/FiO₂. The PaO₂ was kept 45.42±4.10mmHg or so and the SaO₂ was kept 80.47±3.70% or so. The ratio of the ventilation and the blood flow was 3:1 in the pECLA system for 1 hour. The variance of PaO₂, S aO₂ and PaCO₂ was contrasted.Result: The arterial oxygen pressure increased from 45.42±4.10 mmHg to 63.65±3.51 mmHg, the SaO₂ increased from 80.47±3.70 % to 94.65±1.48 % and the PaCO₂ descreased from 35.38±1.74mmHg to 19.32±1.45 mmHg with pumpless extracorporeal lung assist.(P < 0.01)Conclusion: There was significant effect with pumpless extracorporeal lung assist deal with ARDS canine model.