The Study On The Relationship Between PPARγ2 Gene Pro12Ala Polymorphism And Diabetes In Familial Type 2 Diabetes Mellitus Of Uygur In Xinjiang

Objective To analyse the relationship between PPARγ2 gene Pro12Ala polymorphism and diabetes in familial type 2 diabetes mellitus of Uygur in Xinjiang. Methods We chose 62 Uygur type 2 diabetic families and apply PPAP statistic software to analyse the genetic pattern. The polymorphism of PPARγ2gene Pro12Ala measured by SNP-Stream of gene chip method. SPSS13.0 statistic analysis software was used to test the relationship between PPAR-γ2 gene Pro12Ala polymorphism and the first and second degree relative in familial type 2 diabetes mellitus. Results 1)The heritability of the first degree relative in Uygur familial type 2 diabetes was 0.578 and of the second degree relative was 0.032. With the down of the degree relative, the heritability was decreased; 2)There was no significant difference in PPARγ2gene Pro12Ala polymorphism between the first and second degree relative in familial type 2 diabetes mellitus; 3)The all data including BMI,FPG,Lipid and et al) had no significant difference among three kinds of genotypes. Conclusion With the down of the degree relative, the heritability was decreased ; There was no significant difference in PPARγ2 gene Pro12Ala polymorphism between the first and second degree relative in familial type 2 diabetes mellitus.