The Effect Of TiaozhiJi Emulsion On Insulin Resistance Of The Fatty Liver Rat

Objective To establish a hepatic fibrosis model in rat according to multiple factors, compound factors rat fatty liver model by observing TiaozhiJi Emulsion on experimental plot in TC,TG,HDL-C,LDL-C,FBG,ALT,GGT,FLNS,the liver and liver pathology index Detection of such indicators,and calculate HOMA-IR = FBG * FINS/22.5.TiaozhiJi Emulsion of this fatty liver of the validity,reliability,and insulin resistance in the formation of fatty liver's role in the process.Methods 52 Wistar male rats,a week after the laboratory feeding adaptation,randomized divided into five groups,the control group,the control group model of fatty liver,fatty liver model of good easy-treatment group,fatty liver Model medicine TiaozhiJi Emulsion treatment group,fatty liver model of traditional Chinese medicine(Liuwei- dihuang pill) in the treatment group.Combined high-fat emulsion used alcohol fatty liver rat model to Essentiale and Liuweidihuangwan to as a positive control,the use of automatic biochemical analyzer detected TC,TG,HDL-C,LDL-C,ALT and GGT,FBG,using enzyme-linked immunosorbent assay for determination of serum insulin levels.B islet cell function evaluation by homeostasis model assessment(HOMA),or insulin resistance index (HOMA-IR) =(FBG) * FINS/22.5.Results The TC,TG,LDL-C,ALT and GGT,FBG,FINS,HOMA-IR,liver index were higher than those of the normal group,lower HDL-C group.TiaozhiJi Emulsion can reduce the liver index,lower ALT and GGT,TC,TG,LDL-C,FBG,FINS content,lower HOMA-IR.Conclusion TiaozhiJi Emulsion control the mechanism of fatty liver:1.TiaozhiJi Emulsion protect liver cells,and restoration of stability and structure of mitochondrial membrane such as the liver cell functions,and improve liver function.2.TiaozhiJi Emulsion can improve blood lipid metabolism disorders,prevention and treatment of hyperlipidemia. 3.TiaozhiJi Emulsion can improve islet B-cell secretion of the high state and decrease insulin secretion,improving the body's sensitivity to insulin and improve insulin resistance.4.TiaozhiJi Emulsion can reduce rat liver liver index,reduced fat deposition in the liver and improve the role of fatty degeneration of the liver...